Formation and Regulation of Adaptive Response in Nematode Caenorhabditis elegans

الملخص EN

All organisms respond to environmental stresses (e.g., heavy metal, heat, UV irradiation, hyperoxia, food limitation, etc.) with coordinated adjustments in order to deal with the consequences and/or injuries caused by the severe stress.

The nematode Caenorhabditis elegans often exerts adaptive responses if preconditioned with low concentrations of agents or stressor.

In C.

elegans, three types of adaptive responses can be formed: hormesis, cross-adaptation, and dietary restriction.

Several factors influence the formation of adaptive responses in nematodes, and some mechanisms can explain their response formation.

In particular, antioxidation system, heat-shock proteins, metallothioneins, glutathione, signaling transduction, and metabolic signals may play important roles in regulating the formation of adaptive responses.

In this paper, we summarize the published evidence demonstrating that several types of adaptive responses have converged in C.

elegans and discussed some possible alternative theories explaining the adaptive response control.