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Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands
المؤلفون المشاركون
Zhang, Min-Min
Chen, Xia
Liu, Yan-Cheng
Hu, Kun
Peng, Yan
Liang, Hong
Chen, Zhen-Feng
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-05
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Starting from the active ingredient shikimic acid (SA) of traditional Chinese medicine and NH2(CH2)nOH, (n=2–6), we have synthesized a series of new water-soluble Pt(II) complexes PtLa–eCl2, where La–e are chelating diamine ligands with carbon chain covalently attached to SA (La–e = SA-NH(CH2)nNHCH2CH2NH2; La, n=2; Lb, n=3; Lc, n=4; Ld, n=5; Le, n=6).
The results of the elemental analysis, LC-MS, capillary electrophoresis, and 1H, 13C NMR indicated that there was only one product (isomer) formed under the present experimental conditions, in which the coordinate mode of PtLa–eCl2 was two-amine bidentate.
Their in vitro cytotoxic activities were evaluated by MTT method, where these compounds only exhibited low cytotoxicity towards BEL7404, which should correlate their low lipophilicity.
The interactions of the five Pt(II) complexes with DNA were investigated by agarose gel electrophoresis, which suggests that the Pt(II) complexes could induce DNA alteration.
We also studied the interactions of the Pt(II) complexes with 5′-GMP with ESI-MS and 1H NMR and found that PtLbCl2, PtLcCl2, and PtLdCl2 could react with 5′-GMP to form mono-GMP and bis-GMP adducts.
Furthermore, the cell-cycle analysis revealed that PtLbCl2, PtLcCl2 cause cell G2-phase arrest after incubation for 72 h.
Overall, these water-soluble Pt(II) complexes interact with DNA mainly through covalent binding, which blocks the DNA synthesis and replication and thus induces cytotoxicity that weakens as the length of carbon chain increases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Yan& Zhang, Min-Min& Chen, Zhen-Feng& Hu, Kun& Liu, Yan-Cheng& Chen, Xia…[et al.]. 2013. Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands. Bioinorganic Chemistry and Applications،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-481195
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Yan…[et al.]. Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands. Bioinorganic Chemistry and Applications No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-481195
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Yan& Zhang, Min-Min& Chen, Zhen-Feng& Hu, Kun& Liu, Yan-Cheng& Chen, Xia…[et al.]. Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands. Bioinorganic Chemistry and Applications. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-481195
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481195
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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