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On the Hydration State of Amino Acids and Their Derivatives at Different Ionization States : A Comparative Multinuclear NMR and Crystallographic Investigation
المؤلفون المشاركون
Tzakos, Andreas G.
Pappas, Charalampos G.
Gerothanassis, Ioannis P.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
2D, 13C, 14N, and 17O NMR and crystallographic data from the literature were critically evaluated in order to provide a coherent hydration model of amino acids and selected derivatives at different ionization states.
17O shielding variations, longitudinal relaxation times (T1) of 2D and 13C and line widths (Δν1/2) of 14N and 17O, may be interpreted with the hypothesis that the cationic form of amino acids is more hydrated by 1 to 3 molecules of water than the zwitterionic form.
Similar behaviour was also observed for N-acetylated derivatives of amino acids.
An exhaustive search in crystal structure databases demonstrates the importance of six-membered hydrogen-bonded conjugated rings of both oxygens of the α-carboxylate group with a molecule of water in the vicinity.
This type of hydrogen bond mode is absent in the case of the carboxylic groups.
Moreover, a considerable number of structures was identified with the propensity to form intramolecular hydrogen bond both in the carboxylic acid (NH⋯O=C) and in the carboxylate (NH⋯O−) ionization state.
In the presence of bound molecules of water this interaction is significantly reduced in the case of the carboxylate group whereas it is statistically negligible in the carboxylic group.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pappas, Charalampos G.& Tzakos, Andreas G.& Gerothanassis, Ioannis P.. 2012. On the Hydration State of Amino Acids and Their Derivatives at Different Ionization States : A Comparative Multinuclear NMR and Crystallographic Investigation. Journal of Amino Acids،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-481233
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pappas, Charalampos G.…[et al.]. On the Hydration State of Amino Acids and Their Derivatives at Different Ionization States : A Comparative Multinuclear NMR and Crystallographic Investigation. Journal of Amino Acids No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-481233
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pappas, Charalampos G.& Tzakos, Andreas G.& Gerothanassis, Ioannis P.. On the Hydration State of Amino Acids and Their Derivatives at Different Ionization States : A Comparative Multinuclear NMR and Crystallographic Investigation. Journal of Amino Acids. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-481233
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481233
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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