Incorporating a Patient Dichotomous Characteristic in Cancer Phase I Clinical Trials Using Escalation with Overdose Control
المؤلفون المشاركون
Cook-Wiens, Galen
Rogatko, André
Tighiouart, Mourad
المصدر
Journal of Probability and Statistics
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We describe a design for cancer phase I clinical trials that takes into account patients heterogeneity thought to be related to treatment susceptibility.
The goal is to estimate the maximum tolerated dose (MTD) given patient’s specific dichotomous covariate value.
The design is Bayesian adaptive and is an extension of escalation with overdose control (EWOC).
We will assess the performance of this method by comparing the following designs via extensive simulations: (1) design using a covariate; patients are accrued to the trial sequentially and the dose given to a patient depends on his/her baseline covariate value, (2) design ignoring the covariate; patients are accrued to the trial sequentially and the dose given to a patient does not depend on his/her baseline covariate value, and (3) design using separate trials; in each group, patients are accrued to the trial sequentially and EWOC is implemented in each group.
These designs are compared with respect to safety of the trial and efficiency of the estimates of the MTDs via extensive simulations.
We found that ignoring a significant baseline binary covariate in the model results in a substantial number of patients being overdosed.
On the other hand, accounting for a nonsignificant covariate in the model has practically no effect on the safety of the trial and efficiency of the estimates of the MTDs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tighiouart, Mourad& Cook-Wiens, Galen& Rogatko, André. 2012. Incorporating a Patient Dichotomous Characteristic in Cancer Phase I Clinical Trials Using Escalation with Overdose Control. Journal of Probability and Statistics،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-481344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tighiouart, Mourad…[et al.]. Incorporating a Patient Dichotomous Characteristic in Cancer Phase I Clinical Trials Using Escalation with Overdose Control. Journal of Probability and Statistics No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-481344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tighiouart, Mourad& Cook-Wiens, Galen& Rogatko, André. Incorporating a Patient Dichotomous Characteristic in Cancer Phase I Clinical Trials Using Escalation with Overdose Control. Journal of Probability and Statistics. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-481344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر