![](/images/graphics-bg.png)
Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials : Evidences from In Vitro Studies on A375 Cells
المؤلفون المشاركون
Bhattacharyya, Soumya Sundar
Mandal, Sushil Kumar
Dutta, Suman
Biswas, Raktim
Boujedaini, Naoual
Khuda-Bukhsh, Anisur Rahman
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-20
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Crude ethanolic extract of Thuja occidentalis (Fam: Cupressaceae) is used as homeopathic mother tincture (TOΦ) to treat various ailments, particularly moles and tumors, and also used in various other systems of traditional medicine.
Anti-proliferative and apoptosis-inducing properties of TOΦ and the thujone-rich fraction (TRF) separated from it have been evaluated for their possible anti-cancer potentials in the malignant melanoma cell line A375.
On initial trial by S-diphenyltetrazolium bromide assay, both TOΦ and TRF showed maximum cytotoxic effect on A375 cell line while the other three principal fractions separated by chromatography had negligible or no such effect, because of which only TRF was further characterized and subjected to certain other assays for determining its precise anti-proliferative and apoptotic potentials.
TRF was reported to have a molecular formula of C10H16O with a molecular weight of 152.
Exposure of TRF of Thuja occidentalis to A375 cells in vitro showed more cytotoxic, anti-proliferative and apoptotic effects as compared with TOΦ, but had minimal growth inhibitory responses when exposed to normal cells (peripheral blood mononuclear cell).
Furthermore, both TOΦ and TRF also caused a significant decrease in cell viability, induced inter-nucleosomal DNA fragmentation, mitochondrial transmembrane potential collapse, increase in ROS generation, and release of cytochrome c and caspase-3 activation, all of which are closely related to the induction of apoptosis in A375 cells.
Thus, TRF showed and matched all the anti-cancer responses of TOΦ and could be the main bio-active fraction.
The use of TOΦ in traditional medicines against tumors has, therefore, a scientific basis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Biswas, Raktim& Mandal, Sushil Kumar& Dutta, Suman& Bhattacharyya, Soumya Sundar& Boujedaini, Naoual& Khuda-Bukhsh, Anisur Rahman. 2011. Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials : Evidences from In Vitro Studies on A375 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-481374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Biswas, Raktim…[et al.]. Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials : Evidences from In Vitro Studies on A375 Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-481374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Biswas, Raktim& Mandal, Sushil Kumar& Dutta, Suman& Bhattacharyya, Soumya Sundar& Boujedaini, Naoual& Khuda-Bukhsh, Anisur Rahman. Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials : Evidences from In Vitro Studies on A375 Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-481374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)