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Analysis of Polymorphisms in the Lactotransferrin Gene Promoter and Dental Caries
المؤلفون المشاركون
Cordeiro Júnior, Carlos Alberto
Bauer, Peter
Doetzer, Andrea Duarte
Brancher, João Armando
Trevilatto, Paula Cristina
Sotomaior, Vanessa Santos
Medeiros, Kamilla Gabriella dos Santos
Pecharki, Giovana Daniela
المصدر
International Journal of Dentistry
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Regarding host aspects, there has been strong evidence for a genetic component in the etiology of caries.
The salivary protein lactotransferrin (LTF) exhibits antibacterial activity, but there is no study investigating the association of polymorphisms in the promoter region of LTF gene with caries.
The objective of this study was firstly to search the promoter region of the human LTF gene for variations and, if existent, to investigate the association of the identified polymorphisms with dental caries in 12-year-old students.
From 687 unrelated, 12-year-old, both sex students, 50 individuals were selected and divided into two groups of extreme phenotypes according to caries experience: 25 students without (DMFT = 0) and 25 with caries experience (DMFT ≥ 4).
The selection of individuals with extreme phenotypes augments the chances to find gene variations which could be associated with such phenotypes.
LTF gene-putative promoter region (+39 to −1143) of the selected 50 individuals was analyzed by high-resolution melting technique.
Fifteen students, 8 without (DMFT = 0) and 7 with caries experience (mean DMFT = 6.28), presented deviations of the pattern curve suggestive of gene variations and were sequenced.
However, no polymorphisms were identified in the putative promoter region of the LTF gene.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brancher, João Armando& Pecharki, Giovana Daniela& Doetzer, Andrea Duarte& Medeiros, Kamilla Gabriella dos Santos& Cordeiro Júnior, Carlos Alberto& Sotomaior, Vanessa Santos…[et al.]. 2011. Analysis of Polymorphisms in the Lactotransferrin Gene Promoter and Dental Caries. International Journal of Dentistry،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brancher, João Armando…[et al.]. Analysis of Polymorphisms in the Lactotransferrin Gene Promoter and Dental Caries. International Journal of Dentistry No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-481696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brancher, João Armando& Pecharki, Giovana Daniela& Doetzer, Andrea Duarte& Medeiros, Kamilla Gabriella dos Santos& Cordeiro Júnior, Carlos Alberto& Sotomaior, Vanessa Santos…[et al.]. Analysis of Polymorphisms in the Lactotransferrin Gene Promoter and Dental Caries. International Journal of Dentistry. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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