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Effects of Wenxin Keli on the Action Potential and L-Type Calcium Current in Rats with Transverse Aortic Constriction-Induced Heart Failure
المؤلفون المشاركون
Chen, Yu
Guo, Lili
Ai-Ming, Wu
Li, Yang
Chen, Wen
Wang, Jie
Yan-Wei, Xing
Zhao, Mingjing
Yong-Hong, Gao
Li-Xia, Lou
Liu, Xiaoqiu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-11
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
We investigated the effects of WXKL on the action potential (AP) and the L-type calcium current (ICa-L) in normal and hypertrophied myocytes.
Methods.
Forty male rats were randomly divided into two groups: the control group and the transverse aortic constriction- (TAC-) induced heart failure group.
Cardiac hypertrophy was induced by TAC surgery, whereas the control group underwent a sham operation.
Eight weeks after surgery, single cardiac ventricular myocytes were isolated from the hearts of the rats.
The APs and ICa-L were recorded using the whole-cell patch clamp technique.
Results.
The action potential duration (APD) of the TAC group was prolonged compared with the control group and was markedly shortened by WXKL treatment in a dose-dependent manner.
The current densities of the ICa-L in the TAC group treated with 5 g/L WXKL were significantly decreased compared with the TAC group.
We also determined the effect of WXKL on the gating mechanism of the ICa-L in the TAC group.
We found that WXKL decreased the ICa-L by accelerating the inactivation of the channels and delaying the recovery time from inactivation.
Conclusions.
The results suggest that WXKL affects the AP and blocked the ICa-L, which ultimately resulted in the treatment of arrhythmias.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Yu& Li, Yang& Guo, Lili& Chen, Wen& Zhao, Mingjing& Yong-Hong, Gao…[et al.]. 2013. Effects of Wenxin Keli on the Action Potential and L-Type Calcium Current in Rats with Transverse Aortic Constriction-Induced Heart Failure. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-481730
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Yu…[et al.]. Effects of Wenxin Keli on the Action Potential and L-Type Calcium Current in Rats with Transverse Aortic Constriction-Induced Heart Failure. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-481730
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Yu& Li, Yang& Guo, Lili& Chen, Wen& Zhao, Mingjing& Yong-Hong, Gao…[et al.]. Effects of Wenxin Keli on the Action Potential and L-Type Calcium Current in Rats with Transverse Aortic Constriction-Induced Heart Failure. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-481730
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481730
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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