Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level
المؤلفون المشاركون
Huang, Tsun-Tsao
Liu, Jen-Wei
Yu, Sung-Huan
Shih, Chien-Hua
Yeh, So-Wei
Echave, Julian
Hwang, Jenn-Kang
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Functional and biophysical constraints result in site-dependent patterns of protein sequence variability.
It is commonly assumed that the key structural determinant of site-specific rates of evolution is the Relative Solvent Accessibility (RSA).
However, a recent study found that amino acid substitution rates correlate better with two Local Packing Density (LPD) measures, the Weighted Contact Number (WCN) and the Contact Number (CN), than with RSA.
This work aims at a more thorough assessment.
To this end, in addition to substitution rates, we considered four other sequence variability scores, four measures of solvent accessibility (SA), and other CN measures.
We compared all properties for each protein of a structurally and functionally diverse representative dataset of monomeric enzymes.
We show that the best sequence variability measures take into account phylogenetic tree topology.
More importantly, we show that both LPD measures (WCN and CN) correlate better than all of the SA measures, regardless of the sequence variability score used.
Moreover, the independent contribution of the best LPD measure is approximately four times larger than that of the best SA measure.
This study strongly supports the conclusion that a site’s packing density rather than its solvent accessibility is the main structural determinant of its rate of evolution.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yeh, So-Wei& Huang, Tsun-Tsao& Liu, Jen-Wei& Yu, Sung-Huan& Shih, Chien-Hua& Hwang, Jenn-Kang…[et al.]. 2014. Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yeh, So-Wei…[et al.]. Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-481757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yeh, So-Wei& Huang, Tsun-Tsao& Liu, Jen-Wei& Yu, Sung-Huan& Shih, Chien-Hua& Hwang, Jenn-Kang…[et al.]. Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر