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Effects of Endothelial Progenitor Cell-Derived Microvesicles on HypoxiaReoxygenation-Induced Endothelial Dysfunction and Apoptosis
المؤلفون المشاركون
Chen, Ji
Zhao, Bin
Chen, Yanfang
Chen, Shuzhen
Wang, Jinju
Liu, Shiming
Ma, Xiaotang
Cheng, Chuanfang
Xiao, Xiang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Oxidative stress-induced endothelial dysfunction plays a key role in ischemia/reperfusion injury.
Recent evidence indicates that endothelial progenitor cell-derived microvesicles (EPC-MVs) can promote angiogenesis of endothelial cells (ECs).
Here, we investigated the potential effects of EPC-MVs on hypoxia/reoxygenation (H/R) injury in human brain microvascular ECs (hb-ECs).
MVs were prepared from EPCs cultured in a serum deprivation (SD) medium (starving stress, sEPC-MVs) or SD medium containing tumor necrosis factor-α (TNFα) (apoptotic stress, aEPC-MVs).
H/R injury model of hb-ECs was produced by 6 hr hypoxia (1% O2) and 24 hr reoxygenation.
The H/R hb-ECs were co-cultured with EPC-MVs.
Results showed that (1) H/R hb-ECs were dysfunctional and coupled with increased apoptosis and ROS overproduction; (2) under two different conditions, EPCs displayed remarkable difference in caspase 3 and miR126 expression, which were carried by the corresponsive EPC-MVs; (3) functionally, sEPC-MVs had beneficial effects on H/R hb-ECs, whereas aEPC-MVs had detrimental effects; (4) the diverse effects of sEPC-MVs and aEPC-MVs were associated with the changes in miR126 and eNOS expression and were abolished by PI3K inhibitor.
In conclusion, sEPCs-MVs and aEPC-MVs are functionally different on hb-EC apoptosis and dysfunction via their carried RNAs associated with ROS production and PI3K/eNOS/NO pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jinju& Chen, Shuzhen& Ma, Xiaotang& Cheng, Chuanfang& Xiao, Xiang& Chen, Ji…[et al.]. 2013. Effects of Endothelial Progenitor Cell-Derived Microvesicles on HypoxiaReoxygenation-Induced Endothelial Dysfunction and Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jinju…[et al.]. Effects of Endothelial Progenitor Cell-Derived Microvesicles on HypoxiaReoxygenation-Induced Endothelial Dysfunction and Apoptosis. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-481793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jinju& Chen, Shuzhen& Ma, Xiaotang& Cheng, Chuanfang& Xiao, Xiang& Chen, Ji…[et al.]. Effects of Endothelial Progenitor Cell-Derived Microvesicles on HypoxiaReoxygenation-Induced Endothelial Dysfunction and Apoptosis. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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