![](/images/graphics-bg.png)
Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance : An Unusual Presentation of AL Kappa Amyloidosis
المؤلفون المشاركون
Sandhu, Amarpreet
Gabaldon, Darlene
Sun, Yijuan
Servilla, Karen S.
Tzamaloukas, Antonios H.
Danaraj, Jonathan
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
AL amyloidosis complicating monoclonal gammopathy of undetermined significance (MGUS) has usually a predominant glomerular deposition of lambda light chain.
Heavy proteinuria is one of its cardinal manifestations.
A 78-year-old man with a 9-year history of IgG kappa light-chain-MGUS and normal urine protein excretion developed severe renal failure.
Serum levels of kappa light chain and serum IgG had been stable while proteinuria was absent throughout the nine-year period.
For the first eight years, he had stable stage III chronic kidney disease attributed to bladder outlet obstruction secondary to prostatic malignancy.
In the last year, he developed progressive serum creatinine elevation, without any increase in the serum or urine levels of paraproteins or any sign of malignancy.
Renal ultrasound and furosemide renogram showed no evidence of urinary obstruction.
Renal biopsy revealed AL amyloidosis, with reactivity exclusive for kappa light chains, affecting predominantly the vessels and the interstitium.
Glomerular involvement was minimal.
Melphalan and prednisone were initiated.
However, renal function continues deteriorating.
Deposition of AL kappa amyloidosis developing during the course of MGUS predominantly in the wall of the renal vessels and the renal interstitium, while the involvement of the glomeruli is minimal, leads to progressive renal failure and absence of proteinuria.
Renal biopsy is required to detect both the presence and the sites of deposition of renal AL kappa light chain amyloidosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Yijuan& Sandhu, Amarpreet& Gabaldon, Darlene& Danaraj, Jonathan& Servilla, Karen S.& Tzamaloukas, Antonios H.. 2012. Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance : An Unusual Presentation of AL Kappa Amyloidosis. Case Reports in Nephrology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481887
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Yijuan…[et al.]. Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance : An Unusual Presentation of AL Kappa Amyloidosis. Case Reports in Nephrology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-481887
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Yijuan& Sandhu, Amarpreet& Gabaldon, Darlene& Danaraj, Jonathan& Servilla, Karen S.& Tzamaloukas, Antonios H.. Development of Renal Failure without Proteinuria in a Patient with Monoclonal Gammopathy of Undetermined Significance : An Unusual Presentation of AL Kappa Amyloidosis. Case Reports in Nephrology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481887
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-481887
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)