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Xanthium strumarium L. Extracts Produce DNA Damage Mediated by Cytotoxicity in In Vitro Assays but Does Not Induce Micronucleus in Mice
المؤلفون المشاركون
Degrassi, Francesca
De Salvia, Rosella
Cornetta, Tommaso
Sánchez-Lamar, Angel
Cozzi, Renata
Quiñones, Olga
Pérez, Carlos
Valdivia, Dayana
Fiore, Mario
González, Maria L.
Francisco, Marbelis
Stano, Pasquale
Remigio, Antonia
Piloto Ferrer, Janet
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Xanthium strumarium L.
is a member of the Asteraceae commonly used in Cuba, mainly as diuretic.
Some toxic properties of this plant have also been reported and, to date, very little is known about its genotoxic properties.
The present work aims was to evaluate the potential cytotoxic and genotoxic risk of whole extract from Xanthium strumarium L.
whole extract of aerial parts.
No positive response was observed in a battery of four Salmonella typhimurium strains, when exposed to concentrations up to 5 mg/plate, with and without mammalian metabolic activation (liver microsomal S9 fraction from Wistar rats).
In CHO cells, high concentrations (25–100 μg/mL) revealed significant reduction in cell viability.
Results from sister chromatid exchanges, chromosome aberrations, and comet assay showed that X.
strumarium extract is genotoxic at the highest concentration used, when clear cytotoxic effects were also observed.
On the contrary, no increase in micronuclei frequency in bone marrow cells was observed when the extract was orally administered to mice (100, 500, and 2000 mg/Kg doses).
The data presented here constitute the most complete study on the genotoxic potential of X.
strumarium L.
and show that the extract can induce in vitro DNA damage at cytotoxic concentrations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Piloto Ferrer, Janet& Cozzi, Renata& Cornetta, Tommaso& Stano, Pasquale& Fiore, Mario& Degrassi, Francesca…[et al.]. 2014. Xanthium strumarium L. Extracts Produce DNA Damage Mediated by Cytotoxicity in In Vitro Assays but Does Not Induce Micronucleus in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-482020
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Piloto Ferrer, Janet…[et al.]. Xanthium strumarium L. Extracts Produce DNA Damage Mediated by Cytotoxicity in In Vitro Assays but Does Not Induce Micronucleus in Mice. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-482020
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Piloto Ferrer, Janet& Cozzi, Renata& Cornetta, Tommaso& Stano, Pasquale& Fiore, Mario& Degrassi, Francesca…[et al.]. Xanthium strumarium L. Extracts Produce DNA Damage Mediated by Cytotoxicity in In Vitro Assays but Does Not Induce Micronucleus in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-482020
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482020
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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