Adverse Effects of Systemic Immunosuppression in Keratolimbal Allograft
المؤلفون المشاركون
Welder, Jeffrey David
Nassiri, N.
Pandya, H. K.
Djalilian, Ali R.
Krakauer, M.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose.
Keratolimbal allograft (KLAL) is a treatment for limbal stem cell deficiency.
One disadvantage is systemic immunosuppression to avoid rejection.
Our purpose was to examine the adverse effects of systemic immunosuppression in KLAL.
Methods.
A retrospective case review of 16 patients with KLAL who received systemic immunosuppression consisting of a corticosteroid, an antimetabolite, and/or a calcineurin inhibitor was performed.
Patients were monitored for signs, symptoms, or laboratory evidence of toxicity.
Results.
Twelve of 16 patients (75%) experienced an adverse effect.
The average age of those with adverse effects was 50.0 years (SD 17.8) and those without was 23.6 years (SD: 14.3), which was statistically significant (unpaired t-test P=0.022).
Ten of 11 patients (91%) had resolution during mean followup of 16.4 months.
No serious adverse effects occurred.
The most common included anemia, hyperglycemia, elevated creatinine, and elevated liver function tests.
Prednisone and tacrolimus were responsible for the most adverse effects.
More patients with comorbidities experienced adverse effects (83%) than those without comorbidities (25%).
Conclusions.
KLAL requires prolonged systemic immunosuppression.
Our data demonstrated that systemic immunosuppression did not result in serious adverse effects in our population and is relatively safe with monitoring for toxicity.
In addition, we demonstrated that adverse effects occurred more frequently in older patients and those with comorbidities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Krakauer, M.& Welder, Jeffrey David& Pandya, H. K.& Nassiri, N.& Djalilian, Ali R.. 2012. Adverse Effects of Systemic Immunosuppression in Keratolimbal Allograft. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482136
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Krakauer, M.…[et al.]. Adverse Effects of Systemic Immunosuppression in Keratolimbal Allograft. Journal of Ophthalmology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-482136
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Krakauer, M.& Welder, Jeffrey David& Pandya, H. K.& Nassiri, N.& Djalilian, Ali R.. Adverse Effects of Systemic Immunosuppression in Keratolimbal Allograft. Journal of Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482136
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482136
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر