Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage
المؤلفون المشاركون
Dreyfus, Jean-François
Woodhams, Barry
Van Dreden, Patrick
Vasse, Marc
Hue, Guy
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Brain contains large amounts of tissue factor, the major initiator of the coagulation cascade.
Neuronal apoptosis after intracerebral haemorrhage (ICH) leads to the shedding of procoagulant phospholipids (PPLs).
The aim of this study was to investigate the generation of PPL, tissue factor activity (TFa), and D-Dimer (D-Di) in the cerebrospinal fluid (CSF) at the acute phase of ICH in comparison with other brain diseases and to examine the relationship between these factors and the outcome of ICH.
CSF was collected from 112 patients within 48 hours of hospital admission.
Thirty-one patients with no neurological or biochemical abnormalities were used to establish reference range in the CSF (“controls”).
Thirty had suffered an ICH, and 51 other neurological diagnoses [12: ventricular drainage following brain surgery, 13: viral meningitis, 15: bacterial meningitis, and 11 a neurodegenerative disease (NDD)].
PPL was measured using a factor Xa-based coagulation assay and TFa by one home test.
PPL, D-Di, and TFa were significantly higher (P<0.001) in the CSF of patients with ICH than in controls.
TFa levels were significantly (P<0.05) higher in ICH than in patients with meningitides or NDD.
Higher levels (P<0.05) of TFa were observed in patients with ICH who died than in survivors.
TFa measurement in the CSF of patients with ICH could constitute a new prognostic marker.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Van Dreden, Patrick& Hue, Guy& Dreyfus, Jean-François& Woodhams, Barry& Vasse, Marc. 2014. Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage. Advances in Hematology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482142
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Van Dreden, Patrick…[et al.]. Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage. Advances in Hematology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-482142
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Van Dreden, Patrick& Hue, Guy& Dreyfus, Jean-François& Woodhams, Barry& Vasse, Marc. Procoagulant Phospholipids and Tissue Factor Activity in Cerebrospinal Fluid from Patients with Intracerebral Haemorrhage. Advances in Hematology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482142
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482142
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر