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Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H2O2-Induced Cell Apoptosis through Akt Signalling
المؤلفون المشاركون
Lee, Mu-Jang
Liu, Jer-Yuh
Chen, Han-Min
Wang, Chau-Jong
Tzang, Bor-Show
Kao, Shao-Hsuan
Lin, Chiu-Wen
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-08-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Increased cell death of cardiomyocyte by oxidative stress is known to cause dysfunction of the heart.
O.
gratissimum is one of the more well-known medicinal plants among the Ocimum species and widely used in treatment of inflammatory diseases.
In this study, we hypothesized that aqueous extract of O.
gratissimum leaf (OGE) may protect myocardiac cell H9c2 from oxidative injury by hydrogen peroxide (H2O2).
Our results revealed that OGE pretreatment dose-dependently protects H9c2 cells from cell death when exposed to H2O2.
Additionally, DNA condensation induced by H2O2 was also reduced by OGE pretreatment, suggesting that Ocimum gratissimum extract may attenuate H2O2-induced chromosome damage.
Further investigation showed that OGE pretreatment inhibited H2O2-induced activation of caspase-3 and caspase-9, as well as H2O2-induced upregulation of proapoptotic Apaf-1 and the release of cytosolic cytochrome c, but has little effect on the activation of caspase-8.
Additionally, OGE pretreatment significantly upregulated Bcl-2 expression and Akt phosphorylation, and slightly affected the phosphorylation of mitogen-activated protein kinases including p38 MAPK and JNK.
Taken together, our findings revealed that Ocimum gratissimum extract effectively inhibited the mitochondrial pathway and upregulated Bcl-2 expression, which may be important in protecting H9c2 cells from H2O2-induced cell death.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Mu-Jang& Chen, Han-Min& Tzang, Bor-Show& Lin, Chiu-Wen& Wang, Chau-Jong& Liu, Jer-Yuh…[et al.]. 2010. Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H2O2-Induced Cell Apoptosis through Akt Signalling. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Mu-Jang…[et al.]. Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H2O2-Induced Cell Apoptosis through Akt Signalling. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-482172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Mu-Jang& Chen, Han-Min& Tzang, Bor-Show& Lin, Chiu-Wen& Wang, Chau-Jong& Liu, Jer-Yuh…[et al.]. Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H2O2-Induced Cell Apoptosis through Akt Signalling. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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