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Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT
المؤلفون المشاركون
Ford, Charles E.
Arnett, Donna K.
Irvin, Marguerite R.
Eckfeldt, John H.
Davis, Barry R.
Lynch, Amy I.
المصدر
International Journal of Hypertension
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Treatment resistant hypertension (TRH) is defined as uncontrolled hypertension (HTN) despite the use of ≥3 antihypertensive medication classes or controlled HTN while treated with ≥4 antihypertensive medication classes.
Risk factors for TRH include increasing age, diminished kidney function, higher body mass index, diabetes, and African American (AA) race.
Importantly, previous studies suggest a genetic role in TRH, although the genetics of TRH are largely understudied.
With 2203 treatment resistant cases and 2354 treatment responsive controls (36% AA) from the Genetics of Hypertension Associated Treatment Study (GenHAT), we assessed the association of 78 candidate gene polymorphisms with TRH status using logistic regression.
After stratifying by race and adjusting for potential confounders, there were 2 genetic variants in the AGT gene (rs699, rs5051) statistically significantly associated with TRH among white participants.
The Met allele of rs699 and the G allele of rs5051 were positively associated with TRH: OR=1.27 (1.12–1.44), P=0.0001, and OR=1.36 (1.20–1.53), P<0.0001, respectively.
There was no similar association among AA participants (race interaction P=0.0004 for rs699 and P=0.0001 for rs5051).
This research contributes to our understanding of the genetic basis of TRH, and further genetic studies of TRH may help reach the goal of better clinical outcomes for hypertensive patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lynch, Amy I.& Irvin, Marguerite R.& Davis, Barry R.& Ford, Charles E.& Eckfeldt, John H.& Arnett, Donna K.. 2013. Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-482237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lynch, Amy I.…[et al.]. Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT. International Journal of Hypertension No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-482237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lynch, Amy I.& Irvin, Marguerite R.& Davis, Barry R.& Ford, Charles E.& Eckfeldt, John H.& Arnett, Donna K.. Genetic and Adverse Health Outcome Associations with Treatment Resistant Hypertension in GenHAT. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-482237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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