The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats : Experimental Study
المؤلفون المشاركون
Bulbuller, Nurullah
Ozercan, Ibrahim Hanifi
Aygen, Erhan
Basbug, Murat
Camci, Cemalettin
Arikanoglu, Zulfu
Ayten, Refik
Akbulut, Sami
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-28
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
This study determined the effects of a single dose of bevacizumab, an antiangiogenic recombinant monoclonal antibody that specifically targets vascular endothelial growth factor (VEGF), on adhesion formation in the rat cecal abrasion model.
Methodology.
Thirty female Wistar albino rats (200–224 g) were divided into three groups.
All rats underwent laparotomy at which time cecal wall abrasion and abdominal wall injuries were induced.
Group I (control) underwent only the abrasion procedure; Groups II and III received saline or bevacizumab intraperitoneally, respectively, following the abrasion.
The rats were killed on postoperative day 7, and the severity of adhesions was evaluated, together with histopathological fibrosis parameters and immunohistochemical staining to identify the VEGF receptor.
Results.
The mean adhesion severity score in Groups I–III was 2.5±0.52, 2.4±0.69, and 0.7±0.82, respectively; the score in Group III was significantly lower than that in Groups I (P<0.001) and II (P<0.001).
In the histopathological evaluation, the mean fibrosis score in Group III was significantly lower that the scores in Groups I (P<0.001) and II (P<0.001).
VEGF staining of the adhesion areas in Group III was significantly lower than that in Groups I (P<0.001) and II (P<0.001).
Conclusion.
Bevacizumab decreases adhesion formation following laparotomy in rats by blocking VEGF receptor occupancy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Basbug, Murat& Bulbuller, Nurullah& Camci, Cemalettin& Ayten, Refik& Aygen, Erhan& Ozercan, Ibrahim Hanifi…[et al.]. 2011. The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats : Experimental Study. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482252
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Basbug, Murat…[et al.]. The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats : Experimental Study. Gastroenterology Research and Practice No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-482252
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Basbug, Murat& Bulbuller, Nurullah& Camci, Cemalettin& Ayten, Refik& Aygen, Erhan& Ozercan, Ibrahim Hanifi…[et al.]. The Effect of Antivascular Endothelial Growth Factor on the Development of Adhesion Formation in Laparotomized Rats : Experimental Study. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482252
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482252
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر