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Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration
المؤلفون المشاركون
Jimbo, Ryo
Wennerberg, Ann
Mustafa, Kamal
Xue, Ying
Bougas, Kostas
المصدر
International Journal of Biomaterials
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate the early bone response around laminin-1-coated titanium implants.
Forty-five rats distributed in three equally sized groups were provided with one control (turned) and one test (laminin-1-coated) implant and were sacrificed after 3, 7, and 21 days.
Real-time reverse-transcriptase polymerase chain reaction was performed for osteoblast markers (alkaline phosphatase, runt-related transcription factor 2, osteocalcin, type I collagen, and bone morphogenic protein 2), osteoclast markers (cathepsin K and tartrate-resistant acid phosphatase), inflammation markers (tumor necrosis factor α, interleukin 1β and interleukin 10), and integrin β1.
Bone implant contact (BIC) and bone area (BA) were assessed and compared to the gene expression.
After 3 days, the expression of bone markers was higher for the control group.
After 7 days, the expression of integrin β1 and osteogenic markers was enhanced for the test group, while cathepsin K and inflammation markers were down-regulated.
No significant differences in BIC or BA were detected between test and control at any time point.
As a conclusion, implant coating with laminin-1 altered gene expression in the bone-implant interface.
However, traditional evaluation methods, as histomorphometry, were not adequately sensitive to detect such changes due to the short follow-up time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bougas, Kostas& Jimbo, Ryo& Xue, Ying& Mustafa, Kamal& Wennerberg, Ann. 2012. Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration. International Journal of Biomaterials،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bougas, Kostas…[et al.]. Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration. International Journal of Biomaterials No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-482300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bougas, Kostas& Jimbo, Ryo& Xue, Ying& Mustafa, Kamal& Wennerberg, Ann. Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration. International Journal of Biomaterials. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482300
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