Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis

المؤلفون المشاركون

Mangal, Vaishali
Gandhi, Sanjay
Ponnudurai, Kathiresan
Prabhu, Kathiresan
Maurya, Harikesh

المصدر

International Journal of Inflammation

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-06-11

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Present study is to investigate the effect of Gallic acid pretreatment on survival of septic animals and oxidative stress in different organs like lungs, liver, kidney, spleen, and vascular dysfunction of mice.

Sepsis was induced by cecal ligation and puncture (CLP) in healthy adult male albino mice (25–30 g) and was divided into 3 groups each consisting of 6 animals, that is, sham-operated (SO group (Group I), SO + sepsis (Group II), and Gallic acid + sepsis (Group III)).

Group III animals were pretreated with Gallic acid at the dose rate of 20 mg/kg body weight for 2 days before induction of sepsis.

Animals were sacrificed on 8th day and the tissue samples were obtained for further investigation on lipid peroxidation (LPO), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH).

Gallic acid pretreatment significant (P<0.05) reduces kidney, spleen, liver, and lungs’ malondialdehyde level in septic mice.

However, it fails to improve reduced glutathione level in all given organs, while, Gallic acid pretreated mice showed significant improvement in SOD activity of kidney and spleen when compared to septic mice.

Finally, the beneficial effects of Gallic acid pretreatment in sepsis are evident from the observations that Gallic acid partially restored SOD and catalase activity and completely reversed lipid peroxidation.

Further studies are required to find out the possible mechanisms underlying the beneficial effects of Gallic acid on large population.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Maurya, Harikesh& Mangal, Vaishali& Gandhi, Sanjay& Prabhu, Kathiresan& Ponnudurai, Kathiresan. 2014. Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482384

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Maurya, Harikesh…[et al.]. Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis. International Journal of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-482384

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Maurya, Harikesh& Mangal, Vaishali& Gandhi, Sanjay& Prabhu, Kathiresan& Ponnudurai, Kathiresan. Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-482384

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-482384