High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD
المؤلفون المشاركون
Marcos, Jose L.
Fernández-Salazar, Luis
Bernardo Ordiz, David
Barrera, Asterio
León, Alberto J.
Velayos-Jiménez, Benito
Blanco-Quirós, Alfredo
Arranz, Eduardo
Garrote, Jose A.
Gómez, Emma
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-07-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Intestinal alterations in IBD are triggered and maintained by an overexpression of proinflammatory cytokines.
Additionally, increased immune activation has been found in the adjacent intestinal areas without displaying any apparent histological alterations, however, the regulatory environment is not well established.
Biopsy specimens from patients with ulcerative colitis (UC) and Crohn's disease (CD), from both affected and unaffected areas, and also from a group of colonic biopsies from healthy controls, were included in our study.
Cytokines and markers of mucosal damage were analyzed by real-time PCR, and some of the results confirmed by western-blot and ELISA.
Levels of IFNγ, TNFα, IL-6, IL-15, IL-18, and IL-23 were increased (above healthy controls) in both affected and unaffected areas from IBD.
IL-1β, IL-6, IL-12, and IL-27 were higher in affected areas compared to unaffected ones in UC but not CD.
In general, a correlation was observed between mRNA levels of these cytokines and both iNOS and Granzyme B.
SOCS-2 and SOCS-3 were also increased in the affected areas.
In conclusion, the unaffected areas from IBD show increased levels of a restricted set of cytokines that may exert immune activating roles in these areas without being able to trigger tissue damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
León, Alberto J.& Gómez, Emma& Garrote, Jose A.& Bernardo Ordiz, David& Barrera, Asterio& Marcos, Jose L.…[et al.]. 2009. High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-482396
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
León, Alberto J.…[et al.]. High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD. Mediators of Inflammation No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-482396
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
León, Alberto J.& Gómez, Emma& Garrote, Jose A.& Bernardo Ordiz, David& Barrera, Asterio& Marcos, Jose L.…[et al.]. High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-482396
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482396
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر