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Efficacy and Safety of Botulinum Toxin A for Treating Bladder Hyperactivity in Children and Adolescents with Neuropathic Bladder Secondary to Myelomeningocele
المؤلفون المشاركون
Prezioso, Maurizio
Pintozzi, Lucia
Borrelli, Micaela
Marte, Antonio
Parmeggiani, Pio
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-17
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
We verified the efficacy and safety of botulinum toxin A (BTX-A) in treating bladder overactivity in children with neurogenic bladder (NB) secondary to myelomeningocele (MMC).
Forty-seven patients (22, females; 25, males; age range, 5–17 years; mean age, 10.7 years) with poorly compliant/overactive neurogenic bladder on clean intermittent catheterization (CIC) and resistance or noncompliant to anticholinergics were injected with 200 IU of BTX-A intradetrusor.
All patients experienced a significant 66.45% average increase of leak point volume (Wilcoxon paired rank test = 7.169 e-10) and a significant 118.57% average increase of specific bladder capacity at 20 cm H2O (Wilcoxon paired rank test = 2.466 e-12).
Ten patients who presented with concomitant uni/bilateral grade II–IV vesicoureteral reflux were treated at the same time with Deflux.
No patient presented with major perioperative or postoperative problems.
Twenty-two patients needed a second and 18 a third injection of BTX-A after 6–9 months for the reappearance of symptoms.
After a mean follow-up of 5.7 years, 38 out of 47 patients achieved dryness between CICs, and 9 patients improved their incontinence but still need pads.
Our conclusion is that BTX-A represents a viable alternative to more invasive procedure in treatment of overactive NB secondary to MMC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marte, Antonio& Borrelli, Micaela& Prezioso, Maurizio& Pintozzi, Lucia& Parmeggiani, Pio. 2013. Efficacy and Safety of Botulinum Toxin A for Treating Bladder Hyperactivity in Children and Adolescents with Neuropathic Bladder Secondary to Myelomeningocele. Dataset Papers in Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-482458
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marte, Antonio…[et al.]. Efficacy and Safety of Botulinum Toxin A for Treating Bladder Hyperactivity in Children and Adolescents with Neuropathic Bladder Secondary to Myelomeningocele. Dataset Papers in Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-482458
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marte, Antonio& Borrelli, Micaela& Prezioso, Maurizio& Pintozzi, Lucia& Parmeggiani, Pio. Efficacy and Safety of Botulinum Toxin A for Treating Bladder Hyperactivity in Children and Adolescents with Neuropathic Bladder Secondary to Myelomeningocele. Dataset Papers in Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-482458
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482458
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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