Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug
المؤلفون المشاركون
Lee, Jun
Kim, No Soo
Bang, Ok-Sun
Park, Sung Joon
Kim, Bu-Yeo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Descurainia sophia has been traditionally used in Korean medicine for treatment of diverse diseases and their symptoms, such as cough, asthma, and edema.
Our previous results showed that ethanol extract of the seeds of D.
sophia (EEDS) has a potent cytotoxic effect on human cancer cells.
In this study, we reveal the molecular events that are induced by EEDS treatment in A549 human lung cancer cells.
The dose-dependent effect of EEDS on gene expression was measured via a microarray analysis.
Gene ontology and pathway analyses were performed to identify functional involvement of genes regulated by EEDS.
From gene expression analyses, two major dose-dependent patterns were observed after EEDS treatment.
One pattern consisted of 1,680 downregulated genes primarily involved in metabolic processes (FDR < 0.01).
The second pattern consisted of 1,673 upregulated genes primarily involved in signaling processes (FDR < 0.01).
Pathway activity analyses revealed that the metabolism-related pathways and signaling-related pathways were regulated by the EEDS in dose-dependent and reciprocal manners.
In conclusion, the identified biphasic regulatory mechanism involving activation of signaling pathways may provide molecular evidence to explain the inhibitory effect of EEDS on A549 cell growth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Bu-Yeo& Lee, Jun& Park, Sung Joon& Bang, Ok-Sun& Kim, No Soo. 2013. Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-482776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Bu-Yeo…[et al.]. Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-482776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Bu-Yeo& Lee, Jun& Park, Sung Joon& Bang, Ok-Sun& Kim, No Soo. Gene Expression Profile of the A549 Human Non-Small Cell Lung Carcinoma Cell Line following Treatment with the Seeds of Descurainia sophia, a Potential Anticancer Drug. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-482776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر