The Small-Conductance Ca2+-Activated Potassium Channel, Subtype SK3, in the Human Myometrium Is Downregulated in Early Stages of Pregnancy
المؤلفون المشاركون
Poulsen, S. S.
Ødum, L.
Bouchelouche, P.
Klaerke, D. A.
Dahl, M. J.
Rahbek, M.
Larsen, T.
Rosenbaum, S. T.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The human myometrium is mainly relaxed during pregnancy, but, up to term, contractions become more coordinated and forceful in order to initiate delivery.
Small conductance Ca2+-activated K+ channels (SK channels) in human myometrium have been shown to be downregulated in late pregnancy.
The aim was to investigate the presence of SK2 and SK3 in the human myometrium from nonpregnant women, pregnant women at term, and pregnancies delivered preterm and, in addition, to characterize the time of downregulation of these channels.
Using qRT-PCR, we observed significantly lower levels of mRNA for SK2 than for SK3 in the nonpregnant tissue.
The mRNA levels of SK3 were significantly reduced in tissue from pregnancies at term and pregnancies resulting in preterm deliveries, whereas no downregulation for SK2 was observed.
Western blotting confirmed the qRT-PCR results.
Using immunohistochemical staining, both SK2 and SK3 were detected in endometrial glandular epithelium.
We conclude that SK3 mRNA is downregulated early in pregnancy—at least among those that result in preterm deliveries.
Furthermore, we find that SK channels are expressed not only in the uterine smooth muscle but also in the endometrial epithelium.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahbek, M.& Rosenbaum, S. T.& Dahl, M. J.& Klaerke, D. A.& Ødum, L.& Poulsen, S. S.…[et al.]. 2013. The Small-Conductance Ca2+-Activated Potassium Channel, Subtype SK3, in the Human Myometrium Is Downregulated in Early Stages of Pregnancy. Physiology Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahbek, M.…[et al.]. The Small-Conductance Ca2+-Activated Potassium Channel, Subtype SK3, in the Human Myometrium Is Downregulated in Early Stages of Pregnancy. Physiology Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-482793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahbek, M.& Rosenbaum, S. T.& Dahl, M. J.& Klaerke, D. A.& Ødum, L.& Poulsen, S. S.…[et al.]. The Small-Conductance Ca2+-Activated Potassium Channel, Subtype SK3, in the Human Myometrium Is Downregulated in Early Stages of Pregnancy. Physiology Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر