Epigenetic Mechanisms of Genomic Imprinting : Common Themes in the Regulation of Imprinted Regions in Mammals, Plants, and Insects

الملخص EN

Genomic imprinting is a form of epigenetic inheritance whereby the regulation of a gene or chromosomal region is dependent on the sex of the transmitting parent.

During gametogenesis, imprinted regions of DNA are differentially marked in accordance to the sex of the parent, resulting in parent-specific expression.

While mice are the primary research model used to study genomic imprinting, imprinted regions have been described in a broad variety of organisms, including other mammals, plants, and insects.

Each of these organisms employs multiple, interrelated, epigenetic mechanisms to maintain parent-specific expression.

While imprinted genes and imprint control regions are often species and locus-specific, the same suites of epigenetic mechanisms are often used to achieve imprinted expression.

This review examines some examples of the epigenetic mechanisms responsible for genomic imprinting in mammals, plants, and insects.