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Microenvironment Elements Involved in the Development of Pancreatic Cancer Tumor
المؤلفون المشاركون
Gardian, Katarzyna
Janczewska, Sława
Durlik, Marek
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
In spite of intensive research during many years, pancreatic adenocarcinoma remains one of the deadliest cancers.
The surgical intervention remains main possibility of treatment because chemotherapy and radiotherapy has a minimal impact on long-term survival.
We are still looking for the weak points of this devastating disease.
Materials and Methods.
Pancreatic tumor tissue samples were collected from 36 patients.
Immunohistochemistry staining was used to evaluate expression of growth factors and immune infiltrates.
Activity of MMP2 and MMP9 was assessed by gelatin zymography on 7.5% SDS-PAGE gel with 0.1% gelatin.
Results.
All growth factors were strongly expressed in pancreatic tumor tissue.
We found that level of expression of c-Met receptor was higher for G3 tumors than for G2 tumors.
Also we found that active MMP2 was present at all stages of tumor while active MMP9 just at more advanced tumors.
Abundant immune cells infiltration was distinctive for tumor tissue, especially macrophages were infiltrating tumor tissue.
We found that amount of macrophages was associated with lymph nodes metastases.
Conclusion.
In our research we demonstrated that among many factors influencing tumor microenvironment c-Met receptor, infiltrating macrophages and MMP2 have significant influence on development and invasion of pancreatic cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gardian, Katarzyna& Janczewska, Sława& Durlik, Marek. 2012. Microenvironment Elements Involved in the Development of Pancreatic Cancer Tumor. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gardian, Katarzyna…[et al.]. Microenvironment Elements Involved in the Development of Pancreatic Cancer Tumor. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-482869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gardian, Katarzyna& Janczewska, Sława& Durlik, Marek. Microenvironment Elements Involved in the Development of Pancreatic Cancer Tumor. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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