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Systemic Inflammation in Chronic Obstructive Pulmonary Disease : May Adipose Tissue Play a Role? Review of the Literature and Future Perspectives
المؤلف
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-04-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide.
Low-grade systemic inflammation is considered a hallmark of COPD that potentially links COPD to increased rate of systemic manifestations of the disease.
Obesity with/without the metabolic syndrome and cachexia represent two poles of metabolic abnormalities that may relate to systemic inflammation.
On one hand systemic inflammatory syndrome likely reflects inflammation in the lungs, i.e.
results from lung-to plasma spillover of inflammatory mediators.
On the other hand, obesity-related hypoxia results in local inflammatory response within adipose tissue per se, and may contribute to elevations in circulatory mediators by spillover from the adipose tissue to the systemic compartment.
The extent to which systemic hypoxia contributes to the adipose tissue inflammation remains unknown.
We assume that in patients with COPD and concurrent obesity at least three factors play a role in the systemic inflammatory syndrome: the severity of pulmonary impairment, the degree of obesity-related adipose tissue hypoxia, and the severity of systemic hypoxia due to reduced pulmonary functions.
The present review summarizes the epidemiological and clinical evidence linking COPD to obesity, the role of adipose tissue as an endocrine organ, and the role of hypoxia in adipose tissue inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tkacova, Ruzena. 2010. Systemic Inflammation in Chronic Obstructive Pulmonary Disease : May Adipose Tissue Play a Role? Review of the Literature and Future Perspectives. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-482894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tkacova, Ruzena. Systemic Inflammation in Chronic Obstructive Pulmonary Disease : May Adipose Tissue Play a Role? Review of the Literature and Future Perspectives. Mediators of Inflammation No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-482894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tkacova, Ruzena. Systemic Inflammation in Chronic Obstructive Pulmonary Disease : May Adipose Tissue Play a Role? Review of the Literature and Future Perspectives. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-482894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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