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The Relationship between Cocaine Use and Human Papillomavirus Infections in HIV-Seropositive and HIV-Seronegative Women
المؤلفون المشاركون
Plankey, Michael
Burk, Robert
Massad, L. Stewart
Zhong, Ye
D'Souza, Gypsyamber
Palefsky, Joel M.
Levine, Alexandra M.
Strickler, Howard D.
Minkoff, Howard
Watts, D. Heather
Howard, Andrea A.
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-04-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
Animal data suggest that cocaine has an immunosuppressive effect, but no human studies have been conducted to assess the relation of cocaine use with human papillomavirus (HPV) infection, the viral cause of cervical cancer.
Since both cocaine use and HPV infection are common among HIV-positive women, we sought to determine whether use of cocaine and/or crack influences the natural history of HPV among women with or at high risk of HIV.
Methods.
Women enrolled in the Women's Interagency HIV Study (2278 HIV-seropositive and 826 high-risk seronegative women) were examined every six months for up to 9.5 years with Pap smear, collection of cervicovaginal lavage (CVL) samples, and detailed questionnaires regarding health and behavior, including use of crack and cocaine (crack/cocaine).
CVLs were tested for HPV DNA by PCR, with genotyping for over forty HPV types.
Results.
In multivariate logistic regression models, censoring women treated for cervical neoplasia, crack/cocaine use within the last six months was associated with prevalent detection of oncogenic HPV DNA (odds ratio [OR] = 1.30 (1.09–1.55)), and with oncogenic HPV-positive squamous intraepithelial lesions (SIL) (OR = 1.70 (1.27–2.27)), following adjustment for age, race, HIV-serostatus, and CD4+ T-cell count, the number of sexual partners in the past six months, and smoking.
In multivariate Cox models crack/cocaine use was also associated with a trend that approached significance in regard to incident detection of oncogenic HPV-positive SIL (HR = 1.51, 95% CI 0.99–2.30), and while the rate of oncogenic HPV clearance was not related to cocaine use, the clearance of any SIL was significantly lower in those with versus those without recent crack/cocaine use (HR = 0.57, 95% CI 0.34–0.97).
Conclusions.
Cocaine use is associated with an increased risk of detection of both prevalent and incident oncogenic HPV infection, as well as an increased risk of HPV-positive SIL over time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Minkoff, Howard& Zhong, Ye& Strickler, Howard D.& Watts, D. Heather& Palefsky, Joel M.& Levine, Alexandra M.…[et al.]. 2008. The Relationship between Cocaine Use and Human Papillomavirus Infections in HIV-Seropositive and HIV-Seronegative Women. Infectious Diseases in Obstetrics and Gynecology،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-482994
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Minkoff, Howard…[et al.]. The Relationship between Cocaine Use and Human Papillomavirus Infections in HIV-Seropositive and HIV-Seronegative Women. Infectious Diseases in Obstetrics and Gynecology No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-482994
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Minkoff, Howard& Zhong, Ye& Strickler, Howard D.& Watts, D. Heather& Palefsky, Joel M.& Levine, Alexandra M.…[et al.]. The Relationship between Cocaine Use and Human Papillomavirus Infections in HIV-Seropositive and HIV-Seronegative Women. Infectious Diseases in Obstetrics and Gynecology. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-482994
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-482994
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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