Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells
المؤلفون المشاركون
Mancuso, Francesca
Boselli, Carlo
Mazzitelli, Stefania
Becchetti, Ennio
Calvitti, Mario
Nastruzzi, Claudio
Baroni, Tiziano
Ngo Nselel, Monique D.
Luca, Giovanni
Calafiore, Riccardo
Arato, Iva
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-11-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
The limited availability of cadaveric human donor pancreata as well as the incomplete success of the Edmonton protocol for human islet allografts fasten search for new sources of insulin the producing cells for substitution cell therapy of insulin-dependent diabetes mellitus (T1DM).
Starting from isolated neonatal porcine pancreatic islets (NPIs), we have obtained cell monolayers that were exposed to microencapsulated monolayered Sertoli cells (ESCs) for different time periods (7, 14, 21 days).
To assess the development of the cocultured cell monolayers, we have studied either endocrine cell phenotype differentiation markers or c-kit, a hematopoietic stem cell marker, has recently been involved with growth and differentiation of β-cell subpopulations in human as well as rodent animal models.
ESC which were found to either accelerate maturation and differentiation of the NPIs β-cell phenotype or identify an islet cell subpopulation that was marked positively for c-kit.
The insulin/c-kit positive cells might represent a new, still unknown functionally immature β-cell like element in the porcine pancreas.
Acceleration of maturation and differentiation of our NPI cell monolayers might generate a potential new opportunity to develop insulin-producing cells that may suite experimental trials for cell therapy of T1DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mancuso, Francesca& Calvitti, Mario& Luca, Giovanni& Nastruzzi, Claudio& Baroni, Tiziano& Mazzitelli, Stefania…[et al.]. 2009. Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells. Stem Cells International،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-483011
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mancuso, Francesca…[et al.]. Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells. Stem Cells International No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-483011
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mancuso, Francesca& Calvitti, Mario& Luca, Giovanni& Nastruzzi, Claudio& Baroni, Tiziano& Mazzitelli, Stefania…[et al.]. Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells. Stem Cells International. 2009. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-483011
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483011
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر