Bacterial Adaptor Membrane Fusion Proteins and the Structurally Dissimilar Outer Membrane Auxiliary Proteins Have Exchanged Central Domains in α-Proteobacteria

الملخص EN

Transport systems frequently include auxiliary proteins that perform subfunctions within the transporter protein complex.

Two such proteins found in Gram-negative bacteria are the Membrane Fusion Proteins (MFPs) and the Outer Membrane Auxiliary (OMA) proteins.

We here demonstrate that OMAs present in α-proteobacteria (but not in other bacterial types) contain a long α-helical region that is homologous to corresponding regions in the MFPs.

The results suggest that during their evolution, OMAs, specifically from α-proteobacteria, exchanged their own α-helical domain for one derived from an MFP.

The structural and functional implications of these findings are discussed.