Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1Th2 Type Immune Response and Inhibits Larval Development in the Host
المؤلفون المشاركون
Kushwaha, Susheela
Misra-Bhattacharya, Shailja
Singh, Prashant K.
Rana, Ajay K.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-01
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Lymphatic filariasis is a major debilitating disease, endemic in 72 countries putting more than 1.39 billion people at risk and 120 million are already infected.
Despite the significant progress in chemotherapeutic advancements, there is still need for other measures like development of an effective vaccine or discovery of novel drug targets.
In this study, structural and immunological characterization of independent phosphoglycerate mutase of filarial parasite Brugia malayi was carried out.
Protein was found to be expressed in all major parasite life stages and as an excretory secretory product of adult parasites.
Bm-iPGM also reacted to all the categories of human bancroftian patient’s sera including endemic normals.
In vivo immunological behaviour of protein was determined in immunized BALB/c mice followed by prophylactic analysis in BALB/c mice and Mastomys coucha.
Immunization with Bm-iPGM led to generation of a mixed Th1/Th2 type immune response offering 58.2% protection against larval challenge in BALB/c and 65–68% protection in M.
coucha.
In vitro studies confirmed participation of anti-Bm-iPGM antibodies in killing of B.
malayi infective larvae and microfilariae through ADCC mechanism.
The present findings reveal potential immunoprotective nature of Bm-iPGM advocating its worth as an antifilarial vaccine candidate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singh, Prashant K.& Kushwaha, Susheela& Rana, Ajay K.& Misra-Bhattacharya, Shailja. 2014. Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1Th2 Type Immune Response and Inhibits Larval Development in the Host. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-483215
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singh, Prashant K.…[et al.]. Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1Th2 Type Immune Response and Inhibits Larval Development in the Host. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-483215
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singh, Prashant K.& Kushwaha, Susheela& Rana, Ajay K.& Misra-Bhattacharya, Shailja. Cofactor Independent Phosphoglycerate Mutase of Brugia malayi Induces a Mixed Th1Th2 Type Immune Response and Inhibits Larval Development in the Host. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-483215
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483215
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر