Absorption, Distribution, Excretion, and Pharmacokinetics of C14-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats
المؤلفون المشاركون
Park, Sang Hyun
Pradeep, Kannampalli
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-03-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The main objective of this investigation was to determine the absorption, distribution, excretion, and pharmacokinetics of the antimalarial drug pyronaridine tetraphosphate (PNDP) in Sprague-Dawley rats.
Following oral administration of a single dose (10 mg/Kg) of C14-PNDP, it was observed that the drug was readily absorbed from the small intestine within 1 hour following oral administration and was widely distributed in most of the tissues investigated as determined from the observed radioactivity in the tissues.
The peak value of the drug in the blood was reached at around 8 hours postadministration, and radioactivity was detected in most of the tissues from 4 hours onwards.
C14-PNDP showed a poor permeability across the blood-brain barrier, and the absorption, distribution, and excretion of C14-PNDP were found to be gender-independent as both male and female rats showed a similar pattern of radioactivity.
Excretion of the drug was predominantly through the urine with a peak excretion post 24 hours of administration.
A small amount of the drug was also excreted in the feces and also in the breath.
It was found that the Cmax, AUC (0-inf), and Tmax values were similar to those observed in the Phase II clinical trials of pyronaridine/artesunate (Pyramax) conducted in Uganda.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Sang Hyun& Pradeep, Kannampalli. 2010. Absorption, Distribution, Excretion, and Pharmacokinetics of C14-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-483269
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Sang Hyun& Pradeep, Kannampalli. Absorption, Distribution, Excretion, and Pharmacokinetics of C14-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-483269
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Sang Hyun& Pradeep, Kannampalli. Absorption, Distribution, Excretion, and Pharmacokinetics of C14-Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-483269
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483269
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر