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In Vitro Dissolution and In Vivo Bioavailability of Six Brands of Ciprofloxacin Tablets Administered in Rabbits and Their Pharmacokinetic Modeling
المؤلفون المشاركون
Fahmy, Sahar
Abu-Gharbieh, Eman
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study was undertaken to assess the in vitro dissolution and in vivo bioavailability of six brands of ciprofloxacin oral tablets available in the UAE market using rabbits.
The in vitro dissolution profiles of the six ciprofloxacin products were determined using the USP dissolution paddle method.
Pharmacokinetic modeling using compartmental and noncompartmental analysis was done to determine the pharmacokinetic parameters of ciprofloxacin after single-dose oral administration.
In vitro release study revealed that the amount of ciprofloxacin released in 20 minutes was not less than 80% of the labeled amount which is in accordance with the pharmacopoeial requirements.
All tested products are considered to be very rapid dissolving except for formulae A and D.
Ciprofloxacin plasma concentration in rabbits was best fitted to a two-compartment open model.
The lowest bioavailability was determined to be for product A (93.24%) while the highest bioavailability was determined to be for product E (108.01%).
Postmarketing surveillance is very crucial to ensure product quality and eliminating substandard products to be distributed and, consequently, ensure better patient clinical outcome.
The tested ciprofloxacin generic products distributed in the UAE market were proven to be of good quality and could be used interchangeably with the branded ciprofloxacin product.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fahmy, Sahar& Abu-Gharbieh, Eman. 2014. In Vitro Dissolution and In Vivo Bioavailability of Six Brands of Ciprofloxacin Tablets Administered in Rabbits and Their Pharmacokinetic Modeling. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483285
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fahmy, Sahar& Abu-Gharbieh, Eman. In Vitro Dissolution and In Vivo Bioavailability of Six Brands of Ciprofloxacin Tablets Administered in Rabbits and Their Pharmacokinetic Modeling. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-483285
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fahmy, Sahar& Abu-Gharbieh, Eman. In Vitro Dissolution and In Vivo Bioavailability of Six Brands of Ciprofloxacin Tablets Administered in Rabbits and Their Pharmacokinetic Modeling. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-483285
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483285
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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