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Supplementation of T3 Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis
المؤلفون المشاركون
Bhanja, Shravani
Roy, Anita
Mukherjee, Sutapa
Chainy, Gagan B. N.
Samanta, Luna
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Hypothyroidism is a growing medical concern.
There are conflicting reports regarding the mechanism of oxidative stress in hypothyroidism.
Mitochondrial oxidative stress is pivotal to thyroid dysfunction.
The present study aimed to delineate the effects of hepatic inner mitochondrial membrane dysfunction as a consequence of 6-n-propyl-2-thiouracil-induced hypothyroidism in rats.
Increased oxidative stress predominance in the submitochondrial particles (SMP) and altered antioxidant defenses in the mitochondrial matrix fraction correlated with hepatocyte apoptosis.
In order to check whether the effects caused by hypothyroidism are reversed by T3, the above parameters were evaluated in a subset of T3-treated hypothyroid rats.
Complex I activity was inhibited in hypothyroid SMP, whereas T3 supplementation upregulated electron transport chain complexes.
Higher mitochondrial H2O2 levels in hypothyroidism due to reduced matrix GPx activity culminated in severe oxidative damage to membrane lipids.
SMP and matrix proteins were stabilised in hypothyroidism but exhibited increased carbonylation after T3 administration.
Glutathione content was higher in both.
Hepatocyte apoptosis was evident in hypothyroid liver sections; T3 administration, on the other hand, exerted antiapoptotic and proproliferative effects.
Hence, thyroid hormone level critically regulates functional integrity of hepatic mitochondria; hypothyroidism injures mitochondrial membrane lipids leading to hepatocyte apoptosis, which is substantially recovered upon T3 supplementation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mukherjee, Sutapa& Samanta, Luna& Roy, Anita& Bhanja, Shravani& Chainy, Gagan B. N.. 2014. Supplementation of T3 Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-483291
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mukherjee, Sutapa…[et al.]. Supplementation of T3 Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-483291
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mukherjee, Sutapa& Samanta, Luna& Roy, Anita& Bhanja, Shravani& Chainy, Gagan B. N.. Supplementation of T3 Recovers Hypothyroid Rat Liver Cells from Oxidatively Damaged Inner Mitochondrial Membrane Leading to Apoptosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-483291
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483291
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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