Amylenes Do Not Lead to Bacterial Mutagenicity in Contrast to Structurally Related Epoxides
المؤلفون المشاركون
Rosenkranz, Nina
Tüshaus, Carolin
Westphal, Götz A.
Monsé, Christian
Brüning, Thomas
Bünger, Jürgen
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-06
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Amylenes are unsaturated hydrocarbons (C5H10), such as 1-pentene, 2-pentene, 2-methyl-but-1-en (3-methyl-1-butene), 2-methyl-but-2-en (isopentene), and 3-methyl-but-1-en.
We investigated bacterial mutagenicity of 1-pentene, 2-pentene, and 3-methyl-but-1-en in the Ames test.
2-Pentene was investigated as racemate and as pure diastereomers.
We included the methyltransferase deficient Salmonella Typhimurium strain YG7108 and the application of a gas-tight preincubation to reduce the risk of false negative results.
1,2-Epoxypentane which may arise from 1-pentene was used as positive control.
None of the investigated amylenes showed mutagenic effects, whereas 1,2-epoxypentane was mutagenic exceeding 100 μg per plate.
An exceptional high reverse mutation in the negative control plates in the experiments with 1,2-epoxypentane was obviously caused by evaporation into the incubator which was shown by placing the control plates in a separate apparatus.
No differences were seen upon use of YG7108 and its parent strain TA1535.
In conclusion, 1,2-epoxypentane is most probably not a substrate of the deleted bacterial methyltransferases.
The comparison of the bacterial mutagenicity of the investigated amylenes and 1,2-epoxipentane suggests that epoxidation of amylenes in the S9-mix does not proceed effectively or is counterbalanced by detoxifying reactions.
The assessment of mutagenic effects of short chained aliphatic epoxides can be underestimated due to the evaporation of these compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Westphal, Götz A.& Tüshaus, Carolin& Monsé, Christian& Rosenkranz, Nina& Brüning, Thomas& Bünger, Jürgen. 2014. Amylenes Do Not Lead to Bacterial Mutagenicity in Contrast to Structurally Related Epoxides. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-483421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Westphal, Götz A.…[et al.]. Amylenes Do Not Lead to Bacterial Mutagenicity in Contrast to Structurally Related Epoxides. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-483421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Westphal, Götz A.& Tüshaus, Carolin& Monsé, Christian& Rosenkranz, Nina& Brüning, Thomas& Bünger, Jürgen. Amylenes Do Not Lead to Bacterial Mutagenicity in Contrast to Structurally Related Epoxides. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-483421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر