A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide
المؤلفون المشاركون
Iudice, Alfonso
Pizzanelli, Chiara
Guida, Melania
Maestri, Michelangelo
Di Coscio, Elisa
Pelliccia, Veronica
Iacopini, Elena
Giorgi, Filippo Sean
Bonanni, Enrica
المصدر
Epilepsy Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Our aim was to evaluate the EEG and clinical modifications induced by the new antiepileptic drug lacosamide (LCM) in patients with epilepsy.
We evaluated 10 patients affected by focal pharmacoresistant epilepsy in which LCM (mean 250 mg/day) was added to the preexisting antiepileptic therapy, which was left unmodified.
Morning waking EEG recording was performed before (t0) and at 6 months (t1) after starting LCM.
At t0 and t1, patients were also administered questionnaires evaluating mood, anxiety, sleep, sleepiness, and fatigue (Beck Depression Inventory; State-Trait Anxiety Inventory Y1 and Y2; Pittsburgh Sleep Quality Index; Epworth Sleepiness Scale; Fatigue Severity Scale).
We performed a quantitative analysis of EEG interictal abnormalities and background EEG power spectrum analysis.
LCM as an add-on did not significantly affect anxiety, depression, sleepiness, sleep quality, and fatigue scales.
Similarly, adding LCM to preexisting therapy did not modify significantly patient EEGs in terms of absolute power, relative power, mean frequency, and interictal abnormalities occurrence.
In conclusion, in this small cohort of patients, we confirmed that LCM as an add-on does not affect subjective parameters which play a role, among others, in therapy tolerability, and our clinical impression was further supported by evaluation of EEG spectral analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giorgi, Filippo Sean& Pizzanelli, Chiara& Pelliccia, Veronica& Di Coscio, Elisa& Maestri, Michelangelo& Guida, Melania…[et al.]. 2013. A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide. Epilepsy Research and Treatment،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-483507
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giorgi, Filippo Sean…[et al.]. A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide. Epilepsy Research and Treatment No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-483507
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giorgi, Filippo Sean& Pizzanelli, Chiara& Pelliccia, Veronica& Di Coscio, Elisa& Maestri, Michelangelo& Guida, Melania…[et al.]. A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide. Epilepsy Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-483507
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483507
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر