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Identification of MicroRNA as Sepsis Biomarker Based on miRNAs Regulatory Network Analysis
المؤلفون المشاركون
Zhu, Yujie
Sun, Zhandong
Wang, Jian
Chen, Jiajia
Huang, Jie
Shen, Bairong
Lin, Yuxin
Yan, Wenying
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-06
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Sepsis is regarded as arising from an unusual systemic response to infection but the physiopathology of sepsis remains elusive.
At present, sepsis is still a fatal condition with delayed diagnosis and a poor outcome.
Many biomarkers have been reported in clinical application for patients with sepsis, and claimed to improve the diagnosis and treatment.
Because of the difficulty in the interpreting of clinical features of sepsis, some biomarkers do not show high sensitivity and specificity.
MicroRNAs (miRNAs) are small noncoding RNAs which pair the sites in mRNAs to regulate gene expression in eukaryotes.
They play a key role in inflammatory response, and have been validated to be potential sepsis biomarker recently.
In the present work, we apply a miRNA regulatory network based method to identify novel microRNA biomarkers associated with the early diagnosis of sepsis.
By analyzing the miRNA expression profiles and the miRNA regulatory network, we obtained novel miRNAs associated with sepsis.
Pathways analysis, disease ontology analysis, and protein-protein interaction network (PIN) analysis, as well as ROC curve, were exploited to testify the reliability of the predicted miRNAs.
We finally identified 8 novel miRNAs which have the potential to be sepsis biomarkers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Jie& Sun, Zhandong& Yan, Wenying& Zhu, Yujie& Lin, Yuxin& Chen, Jiajia…[et al.]. 2014. Identification of MicroRNA as Sepsis Biomarker Based on miRNAs Regulatory Network Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-483618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Jie…[et al.]. Identification of MicroRNA as Sepsis Biomarker Based on miRNAs Regulatory Network Analysis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-483618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Jie& Sun, Zhandong& Yan, Wenying& Zhu, Yujie& Lin, Yuxin& Chen, Jiajia…[et al.]. Identification of MicroRNA as Sepsis Biomarker Based on miRNAs Regulatory Network Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-483618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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