![](/images/graphics-bg.png)
Comparative Evaluation of Forced Swim Test and Tail Suspension Test as Models of Negative Symptom of Schizophrenia in Rodents
المؤلفون المشاركون
Jaiswal, Manoj
Palit, Gautam
Chatterjee, Manavi
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Previous studies have shown that the administration of NMDA antagonist can induce negative symptoms of schizophrenia which can be tested through the enhanced immobility observed in the forced swim test (FST).
In the present study, we have compared the effects of acute as well as chronic administration of a noncompetitive NMDA receptor antagonist, ketamine on FST, and another behaviour despair model, tail suspension test (TST).
Our observations suggest that chronic ketamine administration induced a state of enhanced immobility in FST, but such findings were not replicated in the TST model.
Further, in FST, treatment with clozapine reverses the ketamine-induced immobility in mice, whereas it enhances the immobility duration in the TST model.
However, haloperidol showed no protective effects in both models.
The data suggests that although both of these tests show common behavioural measure of feeling despair, however, the underlying pathophysiology seems to be different.
Hence, forced swim test but not tail suspension test can be used as a model of negative symptom of psychosis in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chatterjee, Manavi& Jaiswal, Manoj& Palit, Gautam. 2012. Comparative Evaluation of Forced Swim Test and Tail Suspension Test as Models of Negative Symptom of Schizophrenia in Rodents. ISRN Psychiatry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-483692
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chatterjee, Manavi…[et al.]. Comparative Evaluation of Forced Swim Test and Tail Suspension Test as Models of Negative Symptom of Schizophrenia in Rodents. ISRN Psychiatry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-483692
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chatterjee, Manavi& Jaiswal, Manoj& Palit, Gautam. Comparative Evaluation of Forced Swim Test and Tail Suspension Test as Models of Negative Symptom of Schizophrenia in Rodents. ISRN Psychiatry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-483692
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483692
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)