A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma
المؤلفون المشاركون
Chen, Yan
Chao, Enxiang
Chen, Di
Lu, Peng
Yang, Hongjun
Zhang, Fangbo
Liu, Xi
Wen, Shaoxin
Tang, Shihuan
Zhang, Hongchun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine (TCM) has shown significant efficacy in the treatment of cough variant asthma (CVA), a special type of asthma.
However, there is shortage of explanations for relevant mechanism of treatment.
As Zhengs differentiation is a critical concept in TCM, it is necessary to explain the mechanism of treatment of Zhengs.
Based on TCM clinical cases, this study illustrated the mechanism of the treatment of three remarkably relevant Zhengs for CVA: “FengXieFanFei,” “FeiQiShiXuan”, and “QiDaoLuanJi.” To achieve this goal, five steps were carried out: (1) determining feature Zhengs and corresponding key herbs of CVA by analyses of clinical cases; (2) finding out potential targets of the key herbs and clustering them based on their functional annotations; (3) constructing an ingredient-herb network and an ingredient network; (4) identifying modules of the ingredient network; (5) illustrating the mechanism of the treatment by further mining the latent biological implications within each module.
The systematic study reveals that the treatment of “FengXieFanFei,” “FeiQiShiXuan,” and “QiDaoLuanJi” has effects on the regulation of multiple bioprocesses by herbs containing different ingredients with functions of steroid metabolism regulation, airway inflammation, and ion conduction and transportation.
This network-based systematic study will be a good way to boost the scientific understanding of mechanism of the treatment of Zhengs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Di& Zhang, Fangbo& Tang, Shihuan& Chen, Yan& Lu, Peng& Wen, Shaoxin…[et al.]. 2013. A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-483753
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Di…[et al.]. A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-483753
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Di& Zhang, Fangbo& Tang, Shihuan& Chen, Yan& Lu, Peng& Wen, Shaoxin…[et al.]. A Network-Based Systematic Study for the Mechanism of the Treatment of Zhengs Related to Cough Variant Asthma. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-483753
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483753
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر