Large-Scale Protein-Protein Interactions Detection by Integrating Big Biosensing Data with Computational Model
المؤلفون المشاركون
You, Zhu-Hong
Ji, Zhen
Li, Shuai
Gao, Xin
Luo, Xin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Protein-protein interactions are the basis of biological functions, and studying these interactions on a molecular level is of crucial importance for understanding the functionality of a living cell.
During the past decade, biosensors have emerged as an important tool for the high-throughput identification of proteins and their interactions.
However, the high-throughput experimental methods for identifying PPIs are both time-consuming and expensive.
On the other hand, high-throughput PPI data are often associated with high false-positive and high false-negative rates.
Targeting at these problems, we propose a method for PPI detection by integrating biosensor-based PPI data with a novel computational model.
This method was developed based on the algorithm of extreme learning machine combined with a novel representation of protein sequence descriptor.
When performed on the large-scale human protein interaction dataset, the proposed method achieved 84.8% prediction accuracy with 84.08% sensitivity at the specificity of 85.53%.
We conducted more extensive experiments to compare the proposed method with the state-of-the-art techniques, support vector machine.
The achieved results demonstrate that our approach is very promising for detecting new PPIs, and it can be a helpful supplement for biosensor-based PPI data detection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
You, Zhu-Hong& Li, Shuai& Gao, Xin& Luo, Xin& Ji, Zhen. 2014. Large-Scale Protein-Protein Interactions Detection by Integrating Big Biosensing Data with Computational Model. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-483972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
You, Zhu-Hong…[et al.]. Large-Scale Protein-Protein Interactions Detection by Integrating Big Biosensing Data with Computational Model. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-483972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
You, Zhu-Hong& Li, Shuai& Gao, Xin& Luo, Xin& Ji, Zhen. Large-Scale Protein-Protein Interactions Detection by Integrating Big Biosensing Data with Computational Model. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-483972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-483972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر