Functional Genomic and Advanced Genetic Studies Reveal Novel Insights into the Metabolism, Regulation, and Biology of Haloferax volcanii
المؤلف
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The genome sequence of Haloferax volcanii is available and several comparative genomic in silico studies were performed that yielded novel insight for example into protein export, RNA modifications, small non-coding RNAs, and ubiquitin-like Small Archaeal Modifier Proteins.
The full range of functional genomic methods has been established and results from transcriptomic, proteomic and metabolomic studies are discussed.
Notably, Hfx.
volcanii is together with Halobacterium salinarum the only prokaryotic species for which a translatome analysis has been performed.
The results revealed that the fraction of translationally-regulated genes in haloarchaea is as high as in eukaryotes.
A highly efficient genetic system has been established that enables the application of libraries as well as the parallel generation of genomic deletion mutants.
Facile mutant generation is complemented by the possibility to culture Hfx.
volcanii in microtiter plates, allowing the phenotyping of mutant collections.
Genetic approaches are currently used to study diverse biological questions–from replication to posttranslational modification—and selected results are discussed.
Taken together, the wealth of functional genomic and genetic tools make Hfx.
volcanii a bona fide archaeal model species, which has enabled the generation of important results in recent years and will most likely generate further breakthroughs in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Soppa, Joerg. 2011. Functional Genomic and Advanced Genetic Studies Reveal Novel Insights into the Metabolism, Regulation, and Biology of Haloferax volcanii. Archaea،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-484183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Soppa, Joerg. Functional Genomic and Advanced Genetic Studies Reveal Novel Insights into the Metabolism, Regulation, and Biology of Haloferax volcanii. Archaea No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-484183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Soppa, Joerg. Functional Genomic and Advanced Genetic Studies Reveal Novel Insights into the Metabolism, Regulation, and Biology of Haloferax volcanii. Archaea. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-484183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر