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Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD
المؤلفون المشاركون
Pesini, Pedro
Sarasa, Manuel
Boada, Mercè
Pérez-Grijalba, Virginia
Monleón, Inmaculada
San-José, Itziar
Tárraga, Lluís
Martínez-Lage, Pablo
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The present study was aimed at assessing the capability of Aβ1-40 and Aβ1-42 levels in undiluted plasma (UP), diluted plasma (DP), and cell bound (CB) to distinguish between early stages of Alzheimer's disease (AD), amnesic mild cognitive impairment (MCI), and healthy control (HC).
Four blood samples from each participant were collected during one month and the levels of Aβ1-40 and Aβ1-42 were determined by a blinded proprietary ELISA sandwich (Araclon Biotech.
Zaragoza, Spain).
First striking result was that the amount of Aβ1-40 and Aβ1-42 in UP represented only a small proportion (~15%) of the total beta-amyloid pool in blood (βAPB) described here as the sum of Aβ1-40 and Aβ1-42 in blood where they are free in plasma, bound to plasma proteins, and bound to blood cells.
Furthermore, we found that levels of Aβ1-40 and Aβ1-42 in UP, DP, and CB were significantly higher in MCI when compared to HC.
On average, the total βAPB was 1.8 times higher in MCI than in HC (P=0.03) and allowed to discriminate between MCI and HC with a sensitivity and specificity over 80%.
Thus, quantification of several markers of the βAPB could be useful and reliable in the discrimination between MCI and HC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pesini, Pedro& Pérez-Grijalba, Virginia& Monleón, Inmaculada& Boada, Mercè& Tárraga, Lluís& Martínez-Lage, Pablo…[et al.]. 2012. Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-484364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pesini, Pedro…[et al.]. Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-484364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pesini, Pedro& Pérez-Grijalba, Virginia& Monleón, Inmaculada& Boada, Mercè& Tárraga, Lluís& Martínez-Lage, Pablo…[et al.]. Reliable Measurements of the β-Amyloid Pool in Blood Could Help in the Early Diagnosis of AD. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-484364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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