Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb
المؤلفون المشاركون
Garrigue, Jean-Sebastien
Benita, Simon
Daull, Philippe
Buggage, Ronald
Lallemand, Frederic
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-02-27
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Topical ophthalmic delivery of active ingredients can be achieved using cationic nanoemulsions.
In the last decade, Novagali Pharma has successfully developed and marketed Novasorb, an advanced pharmaceutical technology for the treatment of ophthalmic diseases.
This paper describes the main steps in the development of cationic nanoemulsions from formulation to evaluation in clinical trials.
A major challenge of the formulation work was the selection of a cationic agent with an acceptable safety profile that would ensure a sufficient ocular surface retention time.
Then, toxicity and pharmacokinetic studies were performed showing that the cationic emulsions were safe and well tolerated.
Even in the absence of an active ingredient, cationic emulsions were observed in preclinical studies to have an inherent benefit on the ocular surface.
Moreover, clinical trials demonstrated the efficacy and safety of cationic emulsions loaded with cyclosporine A in patients with dry eye disease.
Ongoing studies evaluating latanoprost emulsion in patients with ocular surface disease and glaucoma suggest that the beneficial effects on reducing ocular surface damage may also extend to this patient population.
The culmination of these efforts has been the marketing of Cationorm, a preservative-free cationic emulsion indicated for the symptomatic treatment of dry eye.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lallemand, Frederic& Daull, Philippe& Benita, Simon& Buggage, Ronald& Garrigue, Jean-Sebastien. 2012. Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-484373
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lallemand, Frederic…[et al.]. Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb. Journal of Drug Delivery No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-484373
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lallemand, Frederic& Daull, Philippe& Benita, Simon& Buggage, Ronald& Garrigue, Jean-Sebastien. Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-484373
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484373
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر