![](/images/graphics-bg.png)
ROS-Mediated Signalling in Bacteria : Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress
المؤلفون المشاركون
Ortiz de Orué Lucana, Darío
Wedderhoff, Ina
Groves, Matthew R.
المصدر
Journal of Signal Transduction
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Bacteria are permanently in contact with reactive oxygen species (ROS), both over the course of their life cycle as well that present in their environment.
These species cause damage to proteins, lipids, and nucleotides, negatively impacting the organism.
To detect these ROS molecules and to stimulate the expression of proteins involved in antioxidative stress response, bacteria use a number of different protein-based regulatory and sensory systems.
ROS-based stress detection mechanisms induce posttranslational modifications, resulting in overall conformational and structural changes within sensory proteins.
The subsequent structural rearrangements result in changes of protein activity, which lead to regulated and appropriate response on the transcriptional level.
Many bacterial enzymes and regulatory proteins possess a conserved signature, the zinc-containing redox centre Cys-X-X-Cys in which a disulfide bridge is formed upon oxidative stress.
Other metal-dependent oxidative modifications of amino acid side-chains (dityrosines, 2-oxo-histidines, or carbonylation) also modulate the activity of redox-sensitive proteins.
Using molecular biology, biochemistry, biophysical, and structure biology tools, molecular mechanisms involved in sensing and response to oxidative stress have been elucidated in detail.
In this review, we analyze some examples of bacterial redox-sensing proteins involved in antioxidative stress response and focus further on the currently known molecular mechanism of function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ortiz de Orué Lucana, Darío& Wedderhoff, Ina& Groves, Matthew R.. 2011. ROS-Mediated Signalling in Bacteria : Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ortiz de Orué Lucana, Darío…[et al.]. ROS-Mediated Signalling in Bacteria : Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress. Journal of Signal Transduction No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-484526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ortiz de Orué Lucana, Darío& Wedderhoff, Ina& Groves, Matthew R.. ROS-Mediated Signalling in Bacteria : Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress. Journal of Signal Transduction. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-484526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)