Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors
المؤلفون المشاركون
Bertamino, Alessia
Alcaro, Stefano
Vernieri, Ermelinda
Grieco, Paolo
Gomez-Monterrey, Isabel
Novellino, Ettore
Sala, Marina
Musella, Simona
Milite, Ciro
Campiglia, Pietro
Artese, Anna
Scognamiglio, Ilaria
Ortuso, Francesco
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Cyclooxygenase (COX) is a key enzyme in the biosynthetic pathway leading to the formation of prostaglandins, which are mediators of inflammation.
It exists mainly in two isoforms COX-1 and COX-2.
The conventional nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects because they inhibit both isoforms.
Recent data demonstrate that the overexpression of these enzymes, and in particular of cyclooxygenases-2, promotes multiple events involved in tumorigenesis; in addition, numerous studies show that the inhibition of cyclooxygenases-2 can delay or prevent certain forms of cancer.
Agents that inhibit COX-2 while sparing COX-1 represent a new attractive therapeutic development and offer a new perspective for a further use of COX-2 inhibitors.
The present study extends the evaluation of the COX activity to all 203 possible natural tripeptide sequences following a rational approach consisting in molecular modeling, synthesis, and biological tests.
Based on data obtained from virtual screening, only those peptides with better profile of affinity have been selected and classified into two groups called S and E.
Our results suggest that these novel compounds may have potential as structural templates for the design and subsequent development of the new selective COX-2 inhibitors drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vernieri, Ermelinda& Gomez-Monterrey, Isabel& Milite, Ciro& Grieco, Paolo& Musella, Simona& Bertamino, Alessia…[et al.]. 2013. Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors. Journal of Amino Acids،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-484554
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vernieri, Ermelinda…[et al.]. Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors. Journal of Amino Acids No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-484554
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vernieri, Ermelinda& Gomez-Monterrey, Isabel& Milite, Ciro& Grieco, Paolo& Musella, Simona& Bertamino, Alessia…[et al.]. Design, Synthesis, and Evaluation of New Tripeptides as COX-2 Inhibitors. Journal of Amino Acids. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-484554
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484554
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر