Olmesartan Attenuates Tacrolimus-Induced Biochemical and Ultrastructural Changes in Rat Kidney Tissue
المؤلفون المشاركون
al-Harbi, Mohamed M.
Nadim, Ahmad
Sayed-Ahmed, Mohammed M.
Imam, Faisal
Iqbal, Muzaffar
al-Harbi, Naif O.
Alabidy, Ali D.
Almukhallafi, Ali F.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Tacrolimus, a calcineurin inhibitor, is clinically used as an immunosuppressive agent in organ transplantation, but its use is limited due to its marked nephrotoxicity.
The present study investigated the effect of olmesartan (angiotensin receptor blocker) on tacrolimus-induced nephrotoxicity in rats.
A total of 24 rats were divided into four groups, which included control, tacrolimus, tacrolimus + olmesartan, and olmesartan groups.
Tacrolimus-induced nephrotoxicity was assessed biochemically and histopathologically.
Tacrolimus significantly increased BUN and creatinine level.
Treatment with olmesartan reversed tacrolimus-induced changes in the biochemical markers (BUN and creatinine) of nephrotoxicity.
Tacrolimus significantly decreased GSH level and catalase activity while increasing MDA level.
Olmesartan also attenuated the effects of tacrolimus on MDA, GSH, and catalase.
In tacrolimus group histological examination showed marked changes in renal tubule, mitochondria, and podocyte processes.
Histopathological and ultrastructural studies showed that treatment with olmesartan prevented tacrolimus-induced renal damage.
These results suggest that olmesartan has protective effects on tacrolimus-induced nephrotoxicity, implying that RAS might be playing role in tacrolimus-induced nephrotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Harbi, Naif O.& Imam, Faisal& al-Harbi, Mohamed M.& Iqbal, Muzaffar& Nadim, Ahmad& Sayed-Ahmed, Mohammed M.…[et al.]. 2014. Olmesartan Attenuates Tacrolimus-Induced Biochemical and Ultrastructural Changes in Rat Kidney Tissue. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-484640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Harbi, Naif O.…[et al.]. Olmesartan Attenuates Tacrolimus-Induced Biochemical and Ultrastructural Changes in Rat Kidney Tissue. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-484640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Harbi, Naif O.& Imam, Faisal& al-Harbi, Mohamed M.& Iqbal, Muzaffar& Nadim, Ahmad& Sayed-Ahmed, Mohammed M.…[et al.]. Olmesartan Attenuates Tacrolimus-Induced Biochemical and Ultrastructural Changes in Rat Kidney Tissue. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-484640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر