Maternal and Cord Serum Cytokine Changes with Continuous and Intermittent Labor Epidural Analgesia : A Randomized Study
المؤلفون المشاركون
Ramesh, Vimala
Ramanathan, Sivam
Vallejo, Manuel C.
Jones, Bobby L.
Mantha, Venkat R.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-01
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Background.
Maternal fever during labor epidural analgesia (LEA) may cause increased maternal and cord serum inflammatory cytokines.
We report the effects of intermittent and continuous LEA on these cytokines.
Methods.
Ninety-two women were randomly assigned to continuous (CLEA) or intermittent (ILEA) groups, 46 in each.
Maternal temperature was checked and blood drawn at epidural insertion (baseline) and four-hourly until 4 h postpartum (4 PP).
Cord blood was drawn after placental delivery.
Interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), granulocyte macrophage-colony stimulating factor (GM-CSF), and tumor necrosis factor-α (TNF-α) were measured and analyzed according to group randomization, and then combined and reanalyzed as febrile (temperature ≥38°C) or afebrile groups.
Results.
Significant intragroup changes from baseline were noted in some groups.
Data are pg/mL, median (Q1/Q3).
IL-6 rose at all time points in all groups.
CLEA: baseline: 18.5 (12.5/31.1), 4 h: 80.0 (46.3/110.8), 8 h: 171.9 (145.3/234.3), and 4 PP: 81 (55.7/137.4).
ILEA: baseline: 15.7 (10.2/27.1), 4 h: 68.2 (33.3/95.0), 8 h: 125.0 (86.3/195.0), and 4 PP: 70.2 (54.8/103.6).
Febrile group: baseline: 21.6 (13.8/40.9), 4 h: 83.9 (47.5/120.8), 8 h: 186.7 (149.6/349.9), and 4 PP: 105.8 (65.7/158.8).
Afebrile group: baseline: 10.9 (2.1/17.4), 4 h: 38.2 (15.0/68.2), 8 h: 93.8 (57.1/135.7), and 4 PP: 52.9 (25.1/78).
IL-8 rose at all time points in CLEA: baseline: 2.68 (0.0/4.3), 4 h: 3.7 (0.0/6.5), 8 h: 6.0 (3.3/9.6), 4 PP: 5.6 (0.8/8.0), and afebrile group baseline: 2.5 (0.0/4.7), 4 h: 3.3 (0.0/6.2), 8 h: 5.3 (1.9/9.8), and 4 PP: 4.7 (0.0/7.6).
It fell at 4 PP in febrile group: baseline: 4.1 (0.0/6.4), 4 h: 3.8 (0.0/6.5), 8 h: 5.2 (2.5/8.0), and 4 PP: 2.9 (0.0/4.0).
GM-CSF increased at 8 h and decreased at 4 PP in ILEA baseline: 2.73 (0.0/7.2), 4 h: 2.73 (0.0/7.9), 8 h: 3.9 (2.7/11.5), and 4 PP: 2.0 (0.0/7.2).
It increased at 4 h and 8 h and decreased at 4 PP in febrile group: baseline: 2.6 (0.0/4.2), 4 h: 3.2 (2.1/7.0), 8 h: 4.0 (3.2/12.3), and 4 PP: 2.4 (1.7/12.6).
There were no intergroup cytokine changes in maternal or cord serum in CLEA versus ILEA or febrile versus afebrile groups.
Conclusions.
Some cytokines, especially IL-6, rise physiologically during labor epidural analgesia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mantha, Venkat R.& Vallejo, Manuel C.& Ramesh, Vimala& Jones, Bobby L.& Ramanathan, Sivam. 2012. Maternal and Cord Serum Cytokine Changes with Continuous and Intermittent Labor Epidural Analgesia : A Randomized Study. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mantha, Venkat R.…[et al.]. Maternal and Cord Serum Cytokine Changes with Continuous and Intermittent Labor Epidural Analgesia : A Randomized Study. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-484696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mantha, Venkat R.& Vallejo, Manuel C.& Ramesh, Vimala& Jones, Bobby L.& Ramanathan, Sivam. Maternal and Cord Serum Cytokine Changes with Continuous and Intermittent Labor Epidural Analgesia : A Randomized Study. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-484696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر