Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?
المؤلفون المشاركون
Kotby, Alyaa A.
Abdel Aziz, Manal M.
Moneer, Amira N.
El Guindy, Waleed M.
المصدر
International Journal of Pediatrics
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Tenascin-C (TN-C) is an extracellular matrix glycoprotein that appears at sites of inflammation in cardiac pathologies.
Aim of the Work.
To evaluate the role of TN-C as a marker for active inflammation in children with dilated cardiomyopathy (DCM).
Subjects and Methods.
24 consecutive patients with primary nonfamilial DCM aged 6–72 months (mean 45.19±11.03) were divided into group I, twelve patients with acute onset DCM (<6 months duration), and group II, twelve patients with chronic DCM (>6 months duration), and compared to 20 healthy age- and sex-matched controls.
Investigations included estimation of serum TN-C and echocardiographic evaluation using M-mode and 2D speckle tracking echocardiography (STE).
Results.
Serum TN-C showed a higher significant statistical elevation among patients than controls (P<0.001) and in group I than group II (P<0.001).
EF was significantly decreased, and LVEDD and EDV increased in patients than controls and in GI than GII.
STE showed a statistically significant difference in global peak strain longitudinal (GPSL) average in patients than controls (P<0.05) and between GI and GII (P<0.001).
STE wall motion scoring showed normokinesia (33.5%), hypokinesia (8.33%), and akinesia (50%) in GI and hypokinesia (100%) in GII.
There was a statistically significant positive correlation between serum TN-C and GPSL average.
Conclusions.
Increased serum TN-C can be used as a marker of inflammation in DCM and is associated with the severity of heart failure and LV dysfunction as detected by STE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kotby, Alyaa A.& Abdel Aziz, Manal M.& El Guindy, Waleed M.& Moneer, Amira N.. 2013. Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?. International Journal of Pediatrics،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-484760
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kotby, Alyaa A.…[et al.]. Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?. International Journal of Pediatrics No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-484760
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kotby, Alyaa A.& Abdel Aziz, Manal M.& El Guindy, Waleed M.& Moneer, Amira N.. Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?. International Journal of Pediatrics. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-484760
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484760
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر