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Metabolomic Prediction of Pregnancy Viability in Superovulated Cattle Embryos and Recipients with Fourier Transform Infrared Spectroscopy
المؤلفون المشاركون
Correia, Eva
Muñoz, Marta
Gomez, Enrique
Martin, David
Humblot, Patrice
Ponsart, Claire
Martínez-Bello, Daniel
Uyar, Asli
Trigal, Beatriz
Caamaño, Jose Nestor
Marquant-Le Guienne, Brigitte
Carrocera, Susana
Fernandez-Gonzalez, Alfonso
Guyader-Joly, Catherine
Seli, Emre
Díez, Carmen
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We analyzed embryo culture medium (CM) and recipient blood plasma using Fourier transform infrared spectroscopy (FTIR) metabolomics to identify spectral models predictive of pregnancy outcome.
Embryos collected on Day 6 from superovulated cows in 2 countries were individually cultured in synthetic oviduct fluid medium with BSA for 24 h before embryo transfer.
Spent CM, blank controls, and plasma samples (Day 0 and Day 7) were evaluated using FTIR.
The spectra obtained were analyzed.
The discrimination capability of the classifiers was assessed for accuracy, sensitivity (pregnancy), specificity (nonpregnancy), and area under the ROC curve (AUC).
Endpoints considered were Day 60 pregnancy and birth.
High AUC was obtained for Day 60 pregnancy in CM within individual laboratories (France AUC=0.751±0.039, Spain AUC=0.718±0.024), while cumulative data decreased the AUC (AUC=0.604 ± 0.029).
Predictions for CM at birth were lower than Day 60 pregnancy.
Predictions with plasma at birth improved cumulative over individual results (Day 0: France AUC=0.690±0.044; Spain AUC<0.55; cumulative AUC=0.747±0.032).
Plasma generally predicted pregnancy and birth better than CM.
These first results show that FTIR metabolomics could allow the identification of embryos and recipients with improved pregnancy viability, which may contribute to increasing the efficiency of selection schemes based on ET.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muñoz, Marta& Uyar, Asli& Correia, Eva& Ponsart, Claire& Guyader-Joly, Catherine& Martínez-Bello, Daniel…[et al.]. 2014. Metabolomic Prediction of Pregnancy Viability in Superovulated Cattle Embryos and Recipients with Fourier Transform Infrared Spectroscopy. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-484764
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muñoz, Marta…[et al.]. Metabolomic Prediction of Pregnancy Viability in Superovulated Cattle Embryos and Recipients with Fourier Transform Infrared Spectroscopy. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-484764
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muñoz, Marta& Uyar, Asli& Correia, Eva& Ponsart, Claire& Guyader-Joly, Catherine& Martínez-Bello, Daniel…[et al.]. Metabolomic Prediction of Pregnancy Viability in Superovulated Cattle Embryos and Recipients with Fourier Transform Infrared Spectroscopy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-484764
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484764
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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