Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients
المؤلفون المشاركون
Yan, Andrew T.
Nash, Michelle M.
Connelly, Philip W.
Maguire, Graham F.
Rapi, Lindita
Prasad, G. V. Ramesh
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
South Asian renal transplant recipients have a higher incidence of cardiovascular disease compared with Caucasian renal transplant recipients.
We carried out a study to determine whether paraoxonase 1, a novel biomarker for cardiovascular risk, was decreased in South Asian compared with Caucasian renal transplant recipients.
Subjects were matched two to one on the basis of age and sex for a total of 129 subjects.
Paraoxonase 1 was measured by mass, arylesterase activity, and two-substrate phenotype assay.
Comparisons were made by using a matched design.
The frequency of PON1 QQ, QR and RR phenotype was 56%, 37%, and 7% for Caucasian subjects versus 35%, 44%, and 21% for South Asian subjects (χ2=7.72, P=0.02).
PON1 mass and arylesterase activity were not significantly different between South Asian and Caucasian subjects.
PON1 mass was significantly associated with PON1 phenotype (P=0.0001), HDL cholesterol (P=0.009), LDL cholesterol (P=0.02), and diabetes status (P<0.05).
Arylesterase activity was only associated with HDL cholesterol (P=0.003).
Thus the frequency of the PON1 RR phenotype was higher and that of the QQ phenotype was lower in South Asian versus Caucasian renal transplant recipients.
However, ethnicity was not a significant factor as a determinant of PON1 mass or arylesterase activity, with or without analysis including PON1 phenotype.
The two-substrate method for determining PON1 phenotype may be of value for future studies of cardiovascular complications in renal transplant recipients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Connelly, Philip W.& Maguire, Graham F.& Nash, Michelle M.& Rapi, Lindita& Yan, Andrew T.& Prasad, G. V. Ramesh. 2012. Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients. Journal of Lipids،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Connelly, Philip W.…[et al.]. Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients. Journal of Lipids No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-484765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Connelly, Philip W.& Maguire, Graham F.& Nash, Michelle M.& Rapi, Lindita& Yan, Andrew T.& Prasad, G. V. Ramesh. Paraoxonase 1 Phenotype and Mass in South Asian versus Caucasian Renal Transplant Recipients. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-484765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر