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Evolution of the B-Block Binding Subunit of TFIIIC That Binds to the Internal Promoter for RNA Polymerase III
المؤلف
المصدر
International Journal of Evolutionary Biology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Eukaryotic RNA polymerase III transcribes tRNA genes, and this requires the transcription factor TFIIIC.
Promoters are within genes, with which the B-block binding subunit of TFIIIC associates to initiate transcription.
The binding subunits are more than 1000 amino acids in length in various eukaryotic species.
There are four regions with conserved sequence similarities in the subunits.
The helix-turn-helix motif is included in one of these regions and has been characterized as the B-block_TFIIIC family in the Pfam database.
In the NCBI and EMBL translated protein databases, there are archaeal proteins (approximately 100 amino acids in length) referred to as B-block binding subunits.
Most of them contain a B-block_TFIIIC motif.
DELTA-BLAST searches using these archaeal proteins as queries showed significant multiple blast hits for many eukaryotic B-block binding subunits on the same proteins.
This result suggests that eukaryotic B-block binding subunits were constituted by repeating a small unit of B-block_TFIIIC over a long evolutionary period.
Bacterial proteins have also been annotated as B-block binding subunits in the databases.
Here, some of them were confirmed to have significant similarities to B-block_TFIIIC.
These results may imply that part of the RNAP III transcription machinery existed in the common ancestry of prokaryotes and eukaryotes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Matsutani, Sachiko. 2014. Evolution of the B-Block Binding Subunit of TFIIIC That Binds to the Internal Promoter for RNA Polymerase III. International Journal of Evolutionary Biology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-484901
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Matsutani, Sachiko. Evolution of the B-Block Binding Subunit of TFIIIC That Binds to the Internal Promoter for RNA Polymerase III. International Journal of Evolutionary Biology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-484901
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Matsutani, Sachiko. Evolution of the B-Block Binding Subunit of TFIIIC That Binds to the Internal Promoter for RNA Polymerase III. International Journal of Evolutionary Biology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-484901
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484901
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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