![](/images/graphics-bg.png)
Ginseng (Panax quinquefolius) Reduces Cell Growth, Lipid Acquisition and Increases Adiponectin Expression in 3T3-L1 Cells
المؤلفون المشاركون
Yeo, Chia-Rou
Lee, Sea-Ming
Popovich, David G.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-02-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
An American ginseng (Panax quinquefolius) extract (GE) that contained a quantifiable amount of ginsenosides was investigated for the potential to inhibit proliferation, affect the cell cycle, influence lipid acquisition and adiponectin expression in 3T3-L1 cells.
Six fingerprint ginsenosides were quantified by high performance liquid chromatography and the respective molecular weights were confirmed by LC-ESI-MS analysis.
The extract contained Rg1 (347.3 ± 99.7 μg g−1, dry weight), Re (8280.4 ± 792.3 μg g−1), Rb1 (1585.8 ± 86.8 μg g−1), Rc (32.9 ± 8 μg g−1), Rb2 (62.6 ± 10.6 μg g−1) and Rd (90.4 ± 3.2 μg g−1).
The GE had a dose-dependent effect on 3T3-L1 cell growth, the LC50 value was determined to be 40.3 ± 5 μg ml−1.
Cell cycle analysis showed modest changes in the cell cycle.
No significant changes observed in both G1 and G2/M phases, however there was a significant decrease (P<.05) in the S phase after 24 and 48 h treatment.
Apoptotic cells were modest but significantly (P<.05) increased after 48 h (3.2 ± 1.0%) compared to untreated control cells (1.5 ± 0.1%).
Lipid acquisition was significantly reduced (P<.05) by 13 and 22% when treated at concentrations of 20.2 and 40.3 μg ml−1 compared to untreated control cells.
In relation to adiponectin activation, western blot analysis showed that the protein expression was significantly (P<.05) increased at concentrations tested.
A quantified GE reduced the growth of 3T3-L1 cells, down-regulated the accumulation of lipid and up-regulated the expression of adiponectin in the 3T3-L1 adipocyte cell model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yeo, Chia-Rou& Lee, Sea-Ming& Popovich, David G.. 2011. Ginseng (Panax quinquefolius) Reduces Cell Growth, Lipid Acquisition and Increases Adiponectin Expression in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-484972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yeo, Chia-Rou…[et al.]. Ginseng (Panax quinquefolius) Reduces Cell Growth, Lipid Acquisition and Increases Adiponectin Expression in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-484972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yeo, Chia-Rou& Lee, Sea-Ming& Popovich, David G.. Ginseng (Panax quinquefolius) Reduces Cell Growth, Lipid Acquisition and Increases Adiponectin Expression in 3T3-L1 Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-484972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-484972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)